Synchrony with shunting inhibition in a feedforward inhibitory network.

Journal of Computational Neuroscience
Sachin S TalathiWilliam L Ditto

Abstract

Recent experiments have shown that GABA(A) receptor mediated inhibition in adult hippocampus is shunting rather than hyperpolarizing. Simulation studies of realistic interneuron networks with strong shunting inhibition have been demonstrated to exhibit robust gamma band (20-80 Hz) synchrony in the presence of heterogeneity in the intrinsic firing rates of individual neurons in the network. In order to begin to understand how shunting can contribute to network synchrony in the presence of heterogeneity, we develop a general theoretical framework using spike time response curves (STRC's) to study patterns of synchrony in a simple network of two unidirectionally coupled interneurons (UCI network) interacting through a shunting synapse in the presence of heterogeneity. We derive an approximate discrete map to analyze the dynamics of synchronous states in the UCI network by taking into account the nonlinear contributions of the higher order STRC terms. We show how the approximate discrete map can be used to successfully predict the domain of synchronous 1:1 phase locked state in the UCI network. The discrete map also allows us to determine the conditions under which the two interneurons can exhibit in-phase synchrony. We conclude by...Continue Reading

References

Jan 1, 1993·IMA Journal of Mathematics Applied in Medicine and Biology·M A BurkeJ D Murray
Jul 1, 1996·Neural Computation·B Ermentrout
Dec 1, 1994·Journal of Computational Neuroscience·C Van VreeswijkG B Ermentrout
May 15, 1998·Journal of Computational Neuroscience·J A WhiteN Kopell
Jan 7, 1999·Journal of Computational Neuroscience·C C ChowN Kopell
Feb 27, 1995·Physical Review Letters·U ErnstT Geisel
May 14, 1999·Trends in Cognitive Sciences·C Tallon-Baudry, O Bertrand
Jun 11, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·F AokiG A Ojemann
Feb 13, 2001·Trends in Cognitive Sciences·A K. Engel, W Singer
Jul 4, 2002·The Journal of Physiology·Fiona E N LeBeauEberhard H Buhl
Aug 9, 2002·Journal of Cognitive Neuroscience·Thomas GruberAndreas Keil
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marlene BartosPeter Jonas
Jul 5, 2003·Journal of Computational Neuroscience·Corey D AckerJohn A White
Sep 25, 2003·Biological cybernetics·Henry D I AbarbanelM I Rabinovich
Apr 15, 2005·Journal of Neurophysiology·Boris S GutkinAlex D Reyes
Dec 21, 2006·Nature Reviews. Neuroscience·Marlene BartosPeter Jonas
Feb 15, 2007·Neural Computation·Ho Young Jeong, Boris Gutkin
Jun 20, 2007·Journal of Computational Neuroscience·Selva K Maran, Carmen C Canavier
Feb 26, 2008·Journal of Computational Neuroscience·Sachin S TalathiWilliam L Ditto
May 8, 2009·Journal of Neurophysiology·Jianxia CuiRobert J Butera
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sachin S TalathiWilliam L Ditto

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Citations

Dec 22, 2010·Journal of Computational Neuroscience·Sachin S TalathiPramod P Khargonekar
Oct 15, 2011·Journal of Computational Neuroscience·Erin R BoykinSachin S Talathi
Jan 29, 2011·Journal of Neurophysiology·William C StaceyBrian Litt
Nov 4, 2015·Frontiers in Computational Neuroscience·Shivakeshavan Ratnadurai-GiridharanSachin S Talathi

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