PMID: 8470095Jan 1, 1993Paper

Synchrotron X-ray diffraction and histochemical studies of normal and myopic chick eyes

Tissue & Cell
N J FullwoodK M Meek

Abstract

Synchrotron X-ray diffraction patterns were obtained from the cornea and posterior sclera of control and myopic chicks. No significant differences was found in the interfibrillar or in the intermolecular spacing of the collagen fibrils from the corneas of control and myopic chicks. The intermolecular spacing of myopic sclera was shown to be significantly (p < 0.01) higher than in controls. Sclera and cornea from normal and myopic chicks were stained for proteoglycans using the 'critical electrolyte' method of Scott and Orford (1981). In the sclera, two morphologically distinct types of proteoglycans could be distinguished; one small and usually elongated (approximately 20 nm), the other larger and irregularly shaped. The small proteoglycans were seen binding preferentially to the 'd' and 'e' bands of the collagen fibrils. Small proteoglycans were also present within the fibrils, these were usually approximately 10 nm in diameter although sizes up to 30 nm were observed. Longitudinal sections of fibrils revealed that these intrafibrillar proteoglycans were chiefly orientated parallel to the axis of the collagen fibrils, and preferentially located along the gap region of the fibrils. No difference was observed in the binding site...Continue Reading

References

May 1, 1979·Archives of Ophthalmology·B J CurtinD P Renaldo
Jun 1, 1992·The Histochemical Journal·I M RaweK M Meek
Nov 1, 1991·Biochemical Society Transactions·N A McBrienS Moules
Mar 4, 1991·Biochimica Et Biophysica Acta·A MaroudasP Weinberg
Dec 1, 1990·Current Eye Research·M D GottliebD L Nickla
Jun 20, 1985·The New England Journal of Medicine·E Raviola, T N Wiesel
Feb 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·A J Hodge, F O Schmitt

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Citations

Feb 26, 2011·Micron : the International Research and Review Journal for Microscopy·Nigel J FullwoodSang Joon Lee

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