Syndecan-1 (CD138) deficiency increases Staphylococcus aureus infection but has no effect on pathology in a mouse model of peritoneal dialysis

Journal of Biomedical Science
Paulina M KowalewskaAlison E Fox-Robichaud

Abstract

Technique failure in peritoneal dialysis (PD) due to fibrosis and angiogenesis is complicated by peritonitis. Staphylococcus aureus infection is one of the most common causes of peritonitis in PD. The heparan sulfate proteoglycan, syndecan-1 (CD138), was reported to regulate fibrosis, angiogenesis, inflammation and S. aureus infection. The objectives of this study were to examine the effects of syndecan-1 on S. aureus infection and histopathology in a PD model. Syndecan-1(-/-) and wild type mice were dialyzed for 4 weeks and infected intraperitoneally with S. aureus. Tissues were collected after 4 h for histomorphometric analysis. Intravital microscopy was used to observe leukocyte recruitment and to quantify syndecan-1 in the parietal peritoneum microcirculation. The dialyzed syndecan-1(-/-) mice were more susceptible to S. aureus infection than undialyzed syndecan-1(-/-) controls and wild type animals. However, peritoneal fibrosis and neovascularization due to PD did not differ between syndecan-1(-/-) and wild type mice. Intravital microscopy showed that in S. aureus infection, syndecan-1 was removed from the subendothelial layer of peritoneal venules but syndecan-1 deficiency did not affect leukocyte recruitment. This study ...Continue Reading

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Citations

Mar 1, 2018·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Paulina M KowalewskaAlison E Fox-Robichaud
Jun 18, 2019·Mediators of Inflammation·Paulina RudziakPaulina M Kowalewska

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Methods Mentioned

BETA
lavage
scanning electron microscopy
intravital microscopy

Software Mentioned

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Tescan VegaTC
SlideBook
KaleidaGraph
Synergy

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