Syndecan-4 in intervertebral disc and cartilage: Saint or synner?

Matrix Biology : Journal of the International Society for Matrix Biology
Abbie L A BinchMakarand V Risbud

Abstract

The ECM of the intervertebral disc and articular cartilage contains a highly organised network of collagens and proteoglycans which resist compressive forces applied to these tissues. A pathological hallmark of the intervertebral disc is the imbalance between production of anabolic and catabolic factors by the resident cells. This process is thought to be mediated by pro-inflammatory cytokines, predominantly TNF-α and IL-1β, which upregulate expression of matrix degrading enzymes such as MMPs and ADAMTSs. This imbalance ultimately results in tissue degeneration causing failure of the biomechanical function of the tissues. A similar cascade of events is thought to occur in articular cartilage during development of osteoarthritis. Within these skeletal tissues a small, cell surface heparan sulphate proteoglycan; syndecan-4 (SDC4) has been implicated in maintaining physiological functions. However in the degenerating niche of the intervertebral disc and cartilage, dysregulated activities of this molecule may exacerbate pathological changes. Studies in recent years have elucidated a role for SDC4 in mediating matrix degradation in both intervertebral discs and cartilage by controlling ADAMTS-5 function and MMP3 expression. Discours...Continue Reading

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Citations

Apr 7, 2018·Spine Surgery and Related Research·Sean M RiderJames D Kang
Nov 28, 2020·Osteoarthritis and Cartilage·M BollmannJ Bertrand
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Oct 5, 2021·Experimental and Therapeutic Medicine·Zhidi LinJianyuan Jiang

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