Syndecan-4 over-expression preserves cardiac function in a rat model of myocardial infarction

Journal of Molecular and Cellular Cardiology
Jun XieBiao Xu

Abstract

Syndecan-4 (synd4) is a heparan sulfate proteoglycan, involved in repair following tissue damage, through modulating neovascularization and inflammation. In acute myocardial infarction its myocardial expression is up-regulated in a time-dependent manner, and in synd4-deficient mice severe cardiac dysfunction and abnormal remodeling are observed following induction of myocardial infarction. Here we explored the therapeutic potential of sustained synd4 over-expression in the context of myocardial infarction. Adenovirus containing the synd4 gene (Ad-synd4), or corresponding control adenovirus (Ad-null), was administered intramyocardially in rats immediately after induction of myocardial infarction. Cardiac function was ascertained by echocardiography, hemodynamic assessment and brain natriuretic peptide level 28 days post-intervention. Hearts were excised for molecular and histological analyses at predetermined time points. We observed reduced mortality and improved cardiac function post-myocardial infarction in the Ad-synd4 as compared to the Ad-null group, with associated attenuation of cardiac remodeling, less myocyte loss and reduced fibrosis. Additionally, the Ad-synd4 group exhibited endothelial cell activation and increased...Continue Reading

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Citations

Dec 30, 2014·International Journal of Experimental Pathology·John R CouchmanHinke A B Multhaupt
Apr 22, 2015·The Journal of Infectious Diseases·Takefumi NikaidoMitsuru Munakata
Mar 29, 2016·Biochemical and Biophysical Research Communications·Ran LiBiao Xu
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Aug 20, 2016·Journal of Molecular Histology·Ran LiBiao Xu
Mar 1, 2014·Circulation Research·Marieke RienksStephane Heymans
Oct 12, 2019·International Journal of Molecular Sciences·Yoshinori TaninoYoko Shibata
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Jan 10, 2019·Medical Sciences : Open Access Journal·Giulia Furini, Elisabetta A M Verderio
Feb 19, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Giulia De RossiJames R Whiteford

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