PMID: 2494301Mar 1, 1989Paper

Syndrome of cerebellar ataxia and hypogonadotrophic hypogonadism: evidence for pituitary gonadotrophin deficiency

Journal of Neurology, Neurosurgery, and Psychiatry
A C FokJ S Cheah

Abstract

Familial cerebellar ataxia with hypogonadotrophic hypogonadism is a rare condition. Two affected siblings in a sibship of three were studied and found to have low plasma gonadotrophin levels. No rise in gonadotrophin levels was demonstrable after repeated stimulation with LHRH. The pattern of TSH and prolactin responses to TRH stimulation suggest hypothalamic dysfunction. The results clearly identify the cause of hypogonadism to be due to a defect in production or release of gonadotrophins by the pituitary gland and suggest that hypogonadism is part of a greater endocrine disturbance involving both the hypothalamus and pituitary.

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Citations

Aug 10, 2000·Italian Journal of Neurological Sciences·R RizziP Montagna
Jan 8, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Abdulaziz Alsemari
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Aug 1, 1997·Developmental Medicine and Child Neurology·R H Ruvalcaba
Mar 1, 1993·Annals of Saudi Medicine·A AwadaH Ismail

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