PMID: 3769770Oct 1, 1986Paper

Syndrome of inappropriate antidiuretic hormone with imipramine

Drug Intelligence & Clinical Pharmacy
R A Mitsch, A K Lee

Abstract

Among the various medications that have been associated with the development of syndrome of inappropriate antidiuretic hormone secretion (SIADH) are the tricyclic antidepressants. A 69-year-old man admitted for treatment of a depressive disorder that had not responded to trazodone was prescribed imipramine. Twenty-two days after initiation of therapy, the patient developed hyponatremia. The patient also had depressed serum osmolality and elevated urine sodium concentrations consistent with SIADH. With the discontinuation of imipramine, fluid restriction, and several doses of furosemide, normal serum sodium concentrations were attained. As antidepressant therapy was indicated, doxepin was selected. The patient maintained normal electrolyte values and water balance over the next two months of follow-up. No reports of doxepin-related SIADH were found in the literature; therefore, this agent may be considered as an alternative therapy in patients developing SIADH during antidepressant drug therapy.

References

Jun 1, 1975·Annals of Internal Medicine·J L de Rivera
Dec 5, 1974·The New England Journal of Medicine·A M Moses, M Miller
May 1, 1967·The American Journal of Medicine·F C Bartter, W B Schwartz

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Citations

Jul 27, 2002·Adverse Drug Reactions and Toxicological Reviews·Subramoniam MadhusoodananJorge Sotelo
Feb 12, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Angelica LupatoEnrico Granieri
Dec 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·R Colgate
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W L Robson, J P Nørgaard

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