Syndrome of inappropriate secretion of antidiuretic hormone associated with paroxetine.

Journal of Anesthesia
Takeshi Kubota, Akimasa Miyata

Abstract

A 71-year old man with failed back syndrome was admitted to hospital with oliguria that had occurred 4 days after his dose of paroxetine had been increased to 40 mg x day(-1). Laboratory data on admission revealed hyponatremia (124 mmol x l(-1)), low serum osmolarity (267 mOsm x l(-1)) with a normal level of serum antidiuretic hormone (1.7 pg x ml(-1)), and concentrated urine (430 mOsm x l(-1)). He was diagnosed as having syndrome of inappropriate secretion of antidiuretic hormone, associated with paroxetine; this drug was discontinued immediately after admission. The hyponatremia was treated with saline infusion, water restriction, and furosemide; serum sodium level returned to normal on hospital day 5. Paroxetine is being increasingly used for depression and chronic pain management because of its favorable side-effect profile; however, we should be alert to hyponatremia in patients on paroxetine by carrying out periodic monitoring of serum electrolytes, especially in elderly patients.

References

Jun 1, 1997·Journal of General Internal Medicine·A C JungM Sullivan
Feb 11, 1999·Australian and New Zealand Journal of Medicine·S Paul, S K Sankaran
Apr 6, 1999·British Journal of Clinical Pharmacology·T J WilkinsonR Sainsbury
Aug 24, 1999·Southern Medical Journal·S MadhusoodananO Bogunovic
Dec 10, 1999·Journal of Clinical Pharmacology·M OdehA Oliven
Jun 23, 2001·CNS Drug Reviews·M BourinY Guillon
Sep 12, 2003·Journal of Geriatric Psychiatry and Neurology·Tanya J FabianBruce G Pollock
Apr 5, 2005·Internal Medicine·Masayuki WakitaMitsuhiro Osame

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Citations

Dec 17, 2009·Pharmacy World & Science : PWS·Tetsuro KoideKeiko Watanabe
Dec 19, 2009·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Rebecca StovallKimberly M Crosby
May 15, 2007·La Revue de médecine interne·C BigaillonP Burnat
Feb 2, 2019·International Journal of Psychiatry in Clinical Practice·Siegfried Kasper

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