Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome

Clinical and Experimental Dermatology
K SakumaTetsuo Shiohara

Abstract

Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a severe multiorgan reaction with reactivation of herpesviruses. Various features are often seen during the course of the disease. Many aspects of this syndrome suggest close similarities between DIHS/DRESS and graft-versus-host disease. We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease. In view of previous reports that SIADH and limbic encephalitis are caused by reactivation of latent herpesviruses after transplantation, both conditions may be secondarily caused by reactivation of latent herpesviruses, which is typically observed in DIHS/DRESS. These neurological symptoms should be added to a growing list of important complications of DIHS/DRESS because of the high mortality rate associated with them.

References

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Citations

Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Tetsuo Shiohara, Yoko Kano
Jun 2, 2011·Internal Medicine·Zen KobayashiHidehiro Mizusawa
Apr 11, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Alessandro Peri, Christian Combe
Sep 7, 2011·Annales de dermatologie et de vénéréologie·E Funck-BrentanoL Valeyrie-Allanore
Oct 3, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A AudemardB Hurault de Ligny
Feb 18, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R HaberR Tomb
Jul 20, 2013·The Australasian Journal of Dermatology·Suran L Fernando
May 20, 2011·The American Journal of Medicine·Patrice CacoubJean Claude Roujeau
Nov 28, 2012·Journal of the American Academy of Dermatology·Yukiko UshigomeTetsuo Shiohara
Apr 23, 2013·Journal of the American Academy of Dermatology·Zain HusainRobert A Schwartz
Oct 22, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Tetsuo ShioharaYoko Kano
Dec 13, 2016·Expert Opinion on Drug Safety·Tetsuo Shiohara, Yoko Kano
Mar 15, 2019·The Journal of Dermatology·Jiankang YangMeng Fu
Nov 8, 2019·Current Pharmaceutical Design·Hakan GuvenirEmine Dibek Misirlioglu
Feb 7, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nikolas C VictoriaKrishna A Agarwal
May 21, 2009·Current Opinion in Allergy and Clinical Immunology

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