Syndrome of inappropriate secretion of antidiuretic hormone due to desvenlafaxine

General Hospital Psychiatry
Gary tin-ho Lee, Jess lam-ming Leung


Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is not uncommon in patients receiving treatment of selective serotonin reuptake inhibitors or venlafaxine. This is a case report of a 47-year-old man with depression, who developed hyponatremia after commencing treatment with desvenlafaxine. To our knowledge, this is the first case in which desvenlafaxine-associated SIADH was reported since the introduction of the drug. Physicians should be aware of the possibility of desvenlafaxine-associated hyponatremia in patients under age of 65.


Apr 1, 1997·Journal of Geriatric Psychiatry and Neurology·P RanieriM Trabucchi
Jun 21, 2002·Psychosomatics·James A BourgeoisNeha Bahadur
Aug 10, 2006·The Annals of Pharmacotherapy·Susan Jacob, Sarah A Spinler
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Milton RoxanasMichael Field
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·C EggerC Stuppaeck

Related Concepts

Desvenlafaxine succinate
Involutional Paraphrenia
Inappropriate ADH Syndrome
Mental Depression

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