PMID: 8329791Jun 1, 1993Paper

Syndrome of inappropriate secretion of antidiuretic hormone secondary to fluoxetine

The Annals of Pharmacotherapy
J V Blacksten, J A Birt

Abstract

To report a case of possible fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). A 92-year-old patient was prescribed oral fluoxetine 20 mg daily for depression. After 13 days of therapy, she developed severe weakness and was found to have hyponatremia. Fluoxetine was discontinued. Treatment included fluid restriction and sodium chloride and potassium supplementation. Eight days after admission, the hyponatremia resolved and the patient was discharged without any pharmacologic treatment for depression. Case reports on fluoxetine-induced SIADH were reviewed. Fluoxetine-associated SIADH appears to occur most commonly after short-term therapy in elderly patients. Resolution of hyponatremia occurs six days to two weeks after discontinuation of fluoxetine. Geriatric patients receiving fluoxetine should be monitored regularly to detect abnormal electrolyte values.

References

Apr 1, 1991·The American Journal of Psychiatry·B M VishwanathK A Navalgund
Jul 1, 1990·The American Journal of Psychiatry·B J CohenL Adler
Mar 1, 1989·The American Journal of Psychiatry·A S Hwang, R M Magraw
Dec 1, 1971·Annals of Internal Medicine·M P FichmanN Telfer

Citations

Oct 1, 1995·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·M Leung, R Remick
Aug 10, 2006·The Annals of Pharmacotherapy·Susan Jacob, Sarah A Spinler
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·C EggerC Stuppaeck
Apr 1, 1997·The Australian and New Zealand Journal of Psychiatry·J G LonghurstM B Bowers
Apr 1, 1996·The Australian and New Zealand Journal of Psychiatry·D Burke, S Fanker
Feb 26, 1998·The Annals of Pharmacotherapy·G R MasoodW R Patterson
Apr 1, 1996·The Australian and New Zealand Journal of Psychiatry·E StipJ Bruno
Dec 1, 1993·The Annals of Pharmacotherapy·D M Lisi
Jul 1, 1996·The Annals of Pharmacotherapy·D RobinsonJ I Sheikh
Dec 29, 2000·Journal of Geriatric Psychiatry and Neurology·I E MararJ A Amico
Jul 27, 2002·Adverse Drug Reactions and Toxicological Reviews·Subramoniam MadhusoodananJorge Sotelo
Jul 6, 2007·British Journal of Clinical Pharmacology·N PakravanJ Goddard
Jan 12, 2001·Clinical Neuropharmacology·M C CatalanoW D Taylor
May 29, 2001·International Journal of Geriatric Psychiatry·D Kirby, D Ames

Related Concepts

Fluoxetine Hydrochloride
Inappropriate ADH Syndrome

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

© 2021 Meta ULC. All rights reserved