Syneilesis palmata (Thunb.) Maxim. extract attenuates inflammatory responses via the regulation of TRIF-dependent signaling and inflammasome activation

Journal of Ethnopharmacology
Ji-Won HanKwang-Ho Lee

Abstract

Syneilesis palmata (Thunb.) Maxim. (S. palmata, Asteraceae) is a traditional Korean therapeutic herb widely used to treat pain, arthritis, and other symptoms. This study provides the scientific basis for the anti-inflammatory effects of S. palmata extract (SP) in both in vitro and in vivo experimental models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to study the regulatory effect of SP on the inflammatory mediators in vitro. Bone marrow-derived macrophages were used to study the effects of SP on inflammasome activation. Escherichia coli-induced sepsis mouse model and LPS-induced endotoxin shock model were employed to study the effect of SP on in vivo efficacy. SP inhibited the LPS-stimulated release of proinflammatory mediators, such as nitric oxide and interleukin (IL)-6 in RAW 264.7 cells. SP treatment also attenuated IL-1β secretion via the inhibition of NLRP3 inflammasome activation induced by monosodium urate, ATP, and nigericin. Further, SP ameliorated the severity of NLRP3 inflammasome-mediated symptoms in LPS-induced endotoxin and E. coli-induced sepsis mouse models. Mechanistic studies revealed that inhibitory effects of SP were mediated through the regulation of TRIF-dependent signaling and inf...Continue Reading

References

Sep 18, 2004·Journal of Endotoxin Research·Osamu TakeuchiShizuo Akira
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Mar 21, 2012·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Jul 28, 2013·Science·Nobuhiko KayagakiVishva M Dixit

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Citations

Nov 20, 2019·Inflammation·Lucinéia Gainski DanielskiFabricia Petronilho

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