Synergetic use of neural precursor cells and self-assembling peptides in experimental cervical spinal cord injury

Journal of Visualized Experiments : JoVE
Klaus ZweckbergerM G Fehlings

Abstract

Spinal cord injuries (SCI) cause serious neurological impairment and psychological, economic, and social consequences for patients and their families. Clinically, more than 50% of SCI affect the cervical spine. As a consequence of the primary injury, a cascade of secondary mechanisms including inflammation, apoptosis, and demyelination occur finally leading to tissue scarring and development of intramedullary cavities. Both represent physical and chemical barriers to cell transplantation, integration, and regeneration. Therefore, shaping the inhibitory environment and bridging cavities to create a supportive milieu for cell transplantation and regeneration is a promising therapeutic target. Here, a contusion/compression model of cervical SCI using an aneurysm clip is described. This model is more clinically relevant than other experimental models, since complete transection or ruptures of the cord are rare. Also in comparison to the weight drop model, which in particular damage the dorsum columns, circumferential compression of the spinal cord appears advantageous. Clip closing force and duration can be adjusted to achieve different injury severity. A ring spring facilitates precise calibration and constancy of clip force. Unde...Continue Reading

Citations

Sep 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shushi KabuVinod Labhasetwar
Apr 10, 2019·Neural Regeneration Research·Shuo LiuBin Wang
Feb 2, 2021·ACS Biomaterials Science & Engineering·Sofia SantiClaudio Migliaresi

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