Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study

BMJ : British Medical Journal
Rosalind M GreenA Woodcock

Abstract

To investigate the importance of sensitisation and exposure to allergens and viral infection in precipitating acute asthma in adults resulting in admission to hospital. Case-control study. Large district general hospital. 60 patients aged 17-50 admitted to hospital over a year with acute asthma, matched with two controls: patients with stable asthma recruited from the outpatient department and patients admitted to hospital with non-respiratory conditions (inpatient controls). Atopic status (skin testing and total and specific IgE), presence of common respiratory viruses and atypical bacteria (polymerase chain reaction), dust samples from homes, and exposure to allergens (enzyme linked immunosorbent assay (ELISA): Der p 1, Fel d 1, Can f 1, and Bla g 2). Viruses were detected in 31 of 177 patients. The difference in the frequency of viruses detected between the groups was significant (admitted with asthma 26%, stable asthma 18%, inpatient controls 9%; P=0.04). A significantly higher proportion of patients admitted with asthma (66%) were sensitised and exposed to either mite, cat, or dog allergen than patients with stable asthma (37%) and inpatient controls (15%; P<0.001). Being sensitised and exposed to allergens was an independ...Continue Reading

References

Feb 1, 1991·The Journal of Allergy and Clinical Immunology·S M PollartM D Chapman
Jan 1, 1989·The Journal of Clinical Investigation·R F LemanskeW W Busse
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·D J FraenkelS T Holgate
Oct 16, 1993·BMJ : British Medical Journal·K G NicholsonD C Ireland
Mar 1, 1993·The American Review of Respiratory Disease·L E GelberT A Platts-Mills
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·A CustovicA Woodcock
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·S L JohnstonS T Holgate
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·A CustovicA Woodcock
Aug 1, 1997·The Journal of Allergy and Clinical Immunology·W W Busse, J E Gern
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·K GrünbergP J Sterk
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·D H SmithW B Saunders
Nov 20, 1997·BMJ : British Medical Journal·W T Berrill
Jan 23, 1998·The Journal of Allergy and Clinical Immunology·T A Platts-MillsM D Chapman
May 8, 1999·The European Respiratory Journal·W S TunnicliffeJ G Ayres
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·A SimpsonA Woodcock

❮ Previous
Next ❯

Citations

Feb 20, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Madeleine T KingGuy B Marks
Feb 4, 2003·Current Allergy and Asthma Reports·Sitesh R Roy, Henry Milgrom
Apr 18, 2008·Current Allergy and Asthma Reports·Euan R Tovey
Apr 29, 2010·Current Allergy and Asthma Reports·Sitesh R Roy, Henry Milgrom
Mar 12, 2013·Current Allergy and Asthma Reports·Monica L GavalaJames E Gern
Dec 21, 2002·Allergy·P Van Cauwenberge
Feb 5, 2008·Nature Medicine·Nathan W BartlettSebastian L Johnston
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Robin Gore
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R B Gore, A Custovic
Jul 18, 2003·The New England Journal of Medicine·Ashley WoodcockUNKNOWN Medical Research Council General Practice Research Framework
Mar 18, 2011·The New England Journal of Medicine·William W BusseChristine A Sorkness
Jan 20, 2004·The Pediatric Infectious Disease Journal·James E Gern
Dec 27, 2005·The Pediatric Infectious Disease Journal·Peter W HeymannSebastian L Johnston
Mar 5, 2009·The Pediatric Infectious Disease Journal·Anne B ChangTheo P Sloots
Nov 4, 2010·Current Opinion in Pulmonary Medicine·Dhananjay DesaiChristopher Brightling
Apr 9, 2010·Journal of Virology·James E Gern
Jul 26, 2005·Archives of Disease in Childhood·S T Holgate, G Lack
Aug 29, 2006·Thorax·A M Singh, W W Busse
Sep 30, 2006·Thorax·P A B Wark, P G Gibson
Oct 25, 2006·Annual Review of Medicine·Pedro C Avila
Nov 27, 2010·International Archives of Allergy and Immunology·Zak Callaway, Chang-Keun Kim
Jun 7, 2003·American Journal of Respiratory and Critical Care Medicine·Shashi P SinghMohan L Sopori
Aug 2, 2003·American Journal of Respiratory and Critical Care Medicine·Josephine de KluijverPeter J Sterk
Sep 18, 2004·American Journal of Respiratory and Critical Care Medicine·Jerry A KrishnanCynthia S Rand
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Anne G MosserJames E Gern
May 17, 2005·American Journal of Respiratory and Critical Care Medicine·Terry V GrissellPeter G Gibson
Jun 18, 2005·American Journal of Respiratory and Critical Care Medicine·Sebastian L Johnston, Richard J Martin
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Tom M A WilkinsonJadwiga A Wedzicha
Aug 6, 2011·American Journal of Respiratory and Critical Care Medicine·Loren C DenlingerNizar N Jarjour
Nov 11, 2003·American Journal of Respiratory and Critical Care Medicine·Sebastian L Johnston
Mar 9, 2006·American Journal of Respiratory and Critical Care Medicine·Andrew Bush
Jun 17, 2006·American Journal of Respiratory Cell and Molecular Biology·David Proud, Chung-Wai Chow
May 14, 2008·American Journal of Respiratory Cell and Molecular Biology·Kazuhiro ItoRakesh K Kumar
Jul 9, 2005·Respiratory Research·Luminita A StanciuSebastian L Johnston
Sep 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Paraskevi XepapadakiNikolaos G Papadopoulos
Mar 17, 2012·BMC Medicine·Aran SinganayagamSebastian L Johnston
Apr 20, 2006·Epidemiologic Perspectives & Innovations : EP+I·Linda Kalilani, Julius Atashili
Apr 24, 2009·Proceedings of the American Thoracic Society·Dawn C Newcomb, R Stokes Peebles
Oct 28, 2010·Allergy and Asthma Proceedings·Matthew A RankBarbara P Yawn
Feb 22, 2012·Asia Pacific Allergy·Chang-Keun KimTakao Fujisawa
Jun 25, 2013·Pharmacology & Therapeutics·Audrey H PoonQutayba Hamid
Nov 28, 2013·Scientifica·Marc B Hershenson
Jan 30, 2014·American Journal of Respiratory and Critical Care Medicine·Joshua L KennedyPeter W Heymann
May 23, 2014·The New England Journal of Medicine·Gail M GauvreauJane R Parnes
Oct 3, 2014·Annals of Thoracic Medicine·Abdullah A Alangari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.