Synergism between insecticides permethrin and propoxur occurs through activation of presynaptic muscarinic negative feedback of acetylcholine release in the insect central nervous system

Neurotoxicology
V CorbelBruno Lapied

Abstract

Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cockroach Periplaneta americana) to understand better the physiological process involved in pyrethroid and carbamate interactions. Larval bioassays were conducted with the susceptible reference strain SLAB of C. quinquefasciatus to assess the implication of multi-function oxidases and non-specific esterases in insecticide detoxification and synergism. Results showed that the general theory of synergism (competition between pesticides for a common detoxification enzyme) was unlikely to occur in the SLAB strain since the level of synergy recorded between permethrin and propoxur was unchanged in the presence of piperonyl butoxide and tribufos, two inhibitors of oxidases and esterases, respectively (synergism ratios were similar with and without synergists). We also showed that addition of a sub-lethal concentration of nicotine significantly increased the toxicity of permethrin and propoxur at the lower range of the dose-mortality regression...Continue Reading

Citations

Apr 10, 2008·BMC Evolutionary Biology·Claire BerticatVincent Corbel
Nov 4, 2008·Emerging Infectious Diseases·Cédric PennetierJean-Marc Hougard
May 28, 2013·Parasitology International·Sandra M MiltschGeorg von Samson-Himmelstjerna
Oct 12, 2011·Neuromolecular Medicine·Laila AbdullahFiona Crawford
Sep 25, 2015·Chemosphere·Stephanie RoseArmin Sturm
Jun 26, 2012·Toxicology·Antonio F HernándezOlga López-Guarnido
Mar 3, 2009·Trends in Biotechnology·Bruno LapiedVincent Corbel
Aug 30, 2008·Ecotoxicology and Environmental Safety·Jose L Gomez-EylesDavid J Spurgeon
Jun 10, 2011·Pest Management Science·Neus López-SolerMaria Dolores Garcerá
Jan 9, 2016·Environmental Microbiology Reports·Véronique Apaire-MarchaisBruno Lapied
Oct 3, 2015·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Milena JankowskaJoanna Wyszkowska
Jun 8, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pan WangYi-Jun Wu
Jun 18, 2016·Chemico-biological Interactions·V RizzatiL Gamet-Payrastre
Mar 21, 2016·Toxicon : Official Journal of the International Society on Toxinology·Kai LiuZhigui Duan
Jun 23, 2004·Toxicon : Official Journal of the International Society on Toxinology·Chen-Qi XuCheng-Wu Chi
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milena JankowskaMaria Stankiewicz
Mar 18, 2020·Ecotoxicology and Environmental Safety·Ming-Yuan XuYi-Jun Wu

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