PMID: 14044038Jul 1, 1963

SYNERGISM BETWEEN SULPHONAMIDE DRUGS AND ANTIBIOTICS OF THE POLYMYXIN GROUP AGAINST PROTEUS SP. IN VITRO

Journal of Clinical Pathology
F E RUSSELL
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Abstract

Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wide pH range.

References

The use of colymycin in chronic urinary infections due to Pseudomonas aeuroginosa

Jan 1, 1961·The Journal of Urology·G CARROLL, W F MALETTE

"Colomycin". Laboratory and clinical investigations

Jul 21, 1962·British Medical Journal·G TAYLOR, H ALLISON

Pseudomonas pyocyanea infection treated with colistin methane sulphonate

Oct 13, 1962·Lancet·M MCMILLANG W SCOTT

Citations

Combination of bacteriostatic and bactericidal drugs: lack of significant in vitro antagonism between penicillin, cephalothin, and rolitetracycline

Nov 1, 1976·Antimicrobial Agents and Chemotherapy·F D Daschner

Inducible high resistance to colistin in Proteus strains

Jul 1, 1977·Antimicrobial Agents and Chemotherapy·S ShimizuS Mitsuhashi

Synergism of polymyxin and sulfonamides in L-forms of Staphylococcus aureus and Proteus mirabilis

Apr 1, 1973·Antimicrobial Agents and Chemotherapy·J Z MontgomerieL B Guze

Combined activity of sulfamethoxazole, trimethoprim, and polymyxin B against gram-negative bacilli

Jul 1, 1974·Antimicrobial Agents and Chemotherapy·J E Rosenblatt, P R Stewart

Sulfamethoxazole-trimethoprim-polymyxin therapy of serious multiply drug-resistant Serratia infections

Feb 1, 1976·Antimicrobial Agents and Chemotherapy·F E ThomasR H Alford

Potentiation of inhibitory activity of colistin on Pseudomonas aeruginosa by sulphamethoxazole and sulphamethizole

Sep 20, 1969·British Medical Journal·N A Simmons

Colistin, sulphamethoxazole, and trimethoprim in synergy against Gram-negative bacteria

Dec 1, 1970·Journal of Clinical Pathology·N A Simmons

In vitro additive effect of polymxin B and rifampin against Serratia marcesen

Jun 1, 1975·Antimicrobial Agents and Chemotherapy·W H Traub, I Kleber

Baird-Parker medium supplemented with acriflavine, polymyxins and sulphonamide for the selective isolation of Staphylococcus aureus from heavily contaminated materials

Apr 1, 1981·The Journal of Applied Bacteriology·L A Devriese

Antagonism of colistin-sulphonamide synergism by para-aminobenzoic acid

Mar 26, 1966·Nature·G R Gale, C A Odell

Basis for the selectivity of action of the polymyxin antibiotics on cell membranes

May 10, 1974·Annals of the New York Academy of Sciences·D S FeingoldI J Sud

Maggot therapy: a review of the therapeutic applications of fly larvae in human medicine, especially for treating osteomyelitis

Jul 1, 1988·Medical and Veterinary Entomology·R A Sherman, E A Pechter

A double-blind comparative study of trimethoprim-polymyxin B versus trimethoprim-sulfacetamide-polymyxin B otic solutions in the treatment of otorrhea

Mar 1, 1981·The Journal of Laryngology and Otology·M C Gydé

Related Concepts

Totazina
Polymyxin M
Proteus
Sulfonamides

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