Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

Nature Medicine
P CarmelietM G Persico

Abstract

Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. Both VEGF and PlGF bind to VEGF receptor-1 (VEGFR-1), but it is unknown whether VEGFR-1, which exists as a soluble or a membrane-bound type, is an inert decoy or a signaling receptor for PlGF during angiogenesis. Here, we report that embryonic angiogenesis in mice was not affected by deficiency of PlGF (Pgf-/-). VEGF-B, another ligand of VEGFR-1, did not rescue development in Pgf-/- mice. However, loss of PlGF impaired angiogenesis, plasma extravasation and collateral growth during ischemia, inflammation, wound healing and cancer. Transplantation of wild-type bone marrow rescued the impaired angiogenesis and collateral growth in Pgf-/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow-derived cells. The synergism between PlGF and VEGF was specific, as PlGF deficiency impaired the response to VEGF, but not to bFGF or histamine. VEGFR-1 was activated by PlGF, given that anti-VEGFR-1 antibodies and a Src-kinase inhibitor blocked the endothelial response to PlGF or VEGF/PlGF. By upregulating PlGF an...Continue Reading

References

Feb 14, 1998·The Journal of Clinical Investigation·M ArrasW Schaper
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S HiratsukaM Shibuya
Aug 26, 1998·The Journal of Biological Chemistry·M MigdalG Neufeld
Jan 19, 1999·Journal of Neuro-oncology·M NomuraH Yamamoto
Apr 20, 1999·Biochemical and Biophysical Research Communications·A TakahashiT Tsukamoto
Aug 27, 1999·Biochemical and Biophysical Research Communications·D A SimpsonA W Stitt
Dec 22, 1999·Current Opinion in Biotechnology·B OlofssonK Alitalo
Jan 5, 2000·The Journal of Clinical Investigation·S Rafii
Mar 10, 2000·Seminars in Perinatology·H F Dvorak
Mar 31, 2000·Nature Medicine·P Carmeliet
Mar 31, 2000·Nature Medicine·G ThurstonG D Yancopoulos

❮ Previous
Next ❯

Citations

Mar 12, 2013·Cellular and Molecular Life Sciences : CMLS·Ina M Wittko-SchneiderKarl H Plate
Jan 13, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Vien Khach LaiHusnain Kh Haider
Jan 19, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter A Campochiaro
Oct 12, 2012·Cancer Chemotherapy and Pharmacology·Peter M WilsonHeinz-Josef Lenz
Jan 15, 2009·Acta Neuropathologica·Heike Beck, Karl H Plate
Dec 13, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Margrit HollbornLeon Kohen
Sep 2, 2005·Journal of Cancer Research and Clinical Oncology·Martin RaidaAdrian L Harris
Feb 23, 2008·Angiogenesis·Janice A NagyHarold F Dvorak
Aug 25, 2007·Cancer Metastasis Reviews·Femke Hillen, Arjan W Griffioen
Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
May 7, 2013·Targeted Oncology·Hans PrenenEric Van Cutsem
Oct 19, 2012·Current Allergy and Asthma Reports·Norbert Meyer, Cezmi A Akdis
Apr 2, 2013·Endocrine·Maddalena GiliMaria Felice Brizzi
Nov 6, 2010·Archives of Pharmacal Research·Dong Hyun JoJeong Hun Kim
Apr 21, 2009·Chemical Reviews·Thomas W MillerDavid D Roberts
Mar 29, 2008·Gene Therapy·K-M DebatinC Beltinger
Jul 28, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Timothy KottkeRichard Vile
Jul 20, 2004·Nature Genetics·Lei CaoMatthew J During
Oct 13, 2006·Nature Reviews. Cancer·Francesco BertoliniRobert S Kerbel
Nov 26, 2008·Nature Reviews. Cancer·Christian FischerPeter Carmeliet
Aug 23, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nicola J BrownMalcolm W R Reed
Sep 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eduardo A SilvaDavid J Mooney
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eva-Maria HedlundYihai Cao
Mar 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ricardo J GiordanoWadih Arap
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jenny YaoCarlos Bais
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eva-Maria Eleonora HedlundYihai Cao
Jul 16, 2008·The Journal of Biological Chemistry·Debasree DuttaSoumen Paul
Oct 17, 2008·The Journal of Biological Chemistry·Salvatore PonticelliSandro De Falco
Sep 18, 2002·The Journal of Experimental Medicine·Michael Detmar, Satoshi Hirakawa
Oct 15, 2008·The Journal of Experimental Medicine·Kiichiro YanoWilliam C Aird
May 6, 2008·Tissue Engineering. Part B, Reviews·Zerina Lokmic, Geraldine M Mitchell
Feb 10, 2011·Tissue Engineering. Part a·Soledad Perez-AmodioJohan W van Neck
Feb 13, 2013·Thyroid : Official Journal of the American Thyroid Association·Noriko Makita, Taroh Iiri
Apr 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Astrid A M van der VeldtEgbert F Smit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.