Synergism of ampicillin and gentamicin against obstructive pyelonephritis due to Escherichia coli in rats

The Journal of Infectious Diseases
M P GlauserA I Braude

Abstract

Rats with obstructive pyelonephritis due to Escherichia coli were treated for different intervals with ampicillin and gentamicin either alone or in combination. The combination of ampicillin and gentamicin was synergistic in vitro and significantly more effective in vivo than was either drug alone. After treatment for 10 days, the combination of ampicillin and gentamicin was the only regimen that sterilized all of the pyelonephritic kidneys. The importance of achieving sterility was illustrated by the observation that severe infection and acute pyelonephritis recurred after religation of the ureter in 12 (71%) of 17 ampicillin-treated animals that had harbored as few as 46 organisms per kidney before ligation. A synergistic combination of antibiotics rapidly sterilizes obstructed pyelonephritic kidneys. In view of the particular risk of renal infection in the presence of urinary obstruction in humans, synergistic antibiotic combinations may be useful in the treatment of obstructive pyelonephritis in humans.

Citations

May 1, 1986·Antimicrobial Agents and Chemotherapy·P R MeylanM P Glauser
Feb 1, 1987·Antimicrobial Agents and Chemotherapy·C ThauvinR C Moellering
May 1, 1992·Antimicrobial Agents and Chemotherapy·B Fantin, C Carbon
Oct 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M P GlauserJ Bille

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