Synergism of chronic alcoholism and hepatitis B infection in liver disease

Journal of Gastroenterology and Hepatology
H T ChungA S Lok

Abstract

One hundred and fifty-seven patients with alcoholic liver disease were studied. Hepatitis B surface antigen (HBsAg) was positive in 20.4% of the patients. Those who were positive for the HBsAg presented at an earlier age, had a lower albumin level, a higher globulin level, a more prolonged prothrombin time, were more likely to have features of cirrhosis in the liver biopsy, and were probably more likely to suffer from hepatic encephalopathy in the follow-up compared with those negative for HBsAg. The mortality of subjects was low both on admission and during follow-up. It is concluded that chronic alcoholism and hepatitis B virus infection act synergistically in producing more severe liver damage and causing cirrhosis at a younger age compared with chronic alcoholism alone. One possible reason for the low mortality of the patients might have been their relatively good nutritional status.

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Citations

Sep 1, 1993·Baillière's Clinical Gastroenterology·J B Saunders, N Latt
Sep 1, 1993·Baillière's Clinical Gastroenterology·G L Bird
Jun 26, 1999·Journal of Gastroenterology and Hepatology·J C Imperial
May 31, 2014·World Journal of Gastroenterology : WJG·Teresa Pollicino, Carlo Saitta
Aug 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Danny Ka Ho WongMan Fung Yuen
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Corrao, S Aricò
Feb 2, 2006·The American Journal of Gastroenterology·Brian J McMahon
Nov 1, 1989·Journal of Gastroenterology and Hepatology·D J Frommer

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