PMID: 2511158Nov 15, 1989Paper

Synergism of cisplatin and mitomycin C in sensitive and resistant cell subpopulations of a tumor model

International Journal of Cancer. Journal International Du Cancer
R E Durand

Abstract

Cisplatin is a widely-used anti-neoplastic agent with activity against a broad spectrum of human solid tumors. It is, however, seldom curative as a single agent. In an in vitro tumor model system, V79 spheroids, the non-cycling, hypoxic cell subpopulations are most resistant to cisplatin, suggesting that combination chemotherapy with cisplatin and a drug which preferentially killed hypoxic cells might prove useful. Mitomycin C has the latter activity, and was thus evaluated. Not only was the expected complementary toxicity observed in combination treatments, but synergism between the drugs was found at clinically relevant drug doses. Further, both the net pattern of cell killing and the degree of interaction between the agents were a function of the dose ratios of the drugs in the combination treatments. The ability of mitomycin C to potentiate the response of cells resistant to cisplatin as a single agent may thus prove of value in clinical protocols.

References

Mar 1, 1979·Cancer Treatment Reviews·A W PrestaykoS T Crooke
Sep 1, 1976·Cell and Tissue Kinetics·R E Durand
Nov 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D S AlbertsE V Hannigan
Jan 18, 1989·Journal of the National Cancer Institute·R E Durand
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S D YoungR P Hill
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G C RiceR T Schimke
Aug 1, 1982·In Vitro·P L OliveR E Durand

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Citations

Nov 8, 2006·Diseases of the Colon and Rectum·Gilles CrehangeJean François Bosset
Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R E Durand, N E LePard
Oct 18, 2000·Critical Reviews in Oncology/hematology·B Desoize, J Jardillier
Nov 11, 2016·Cancer Chemotherapy and Pharmacology·In Hee LeeJong Gwang Kim

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