PMID: 1597204Mar 1, 1992Paper

Synergism of trimethoprim and ciprofloxacin in vitro against clinical bacterial isolates

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
P HuovinenD C Hooper

Abstract

For the first time, the effects of combinations of trimethoprim and a fluoroquinolone (ciprofloxacin) against gram-positive and gram-negative bacterial isolates were evaluated in vitro. Synergism was found in 31% (fractional inhibitory concentration, FIC) and 33% (fractional bactericidal concentration, FBC) of 121 clinical isolates of various bacterial strains, most often in Escherichia coli, staphylococci, and enterococci. Antagonism occurred in 1% (FIC) and 3% (FBC). The combination of trimethoprim and ciprofloxacin merits further evaluation for potential usefulness as a clinical regimen.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M GellertJ I Tomizawa
Feb 1, 1990·The Journal of Antimicrobial Chemotherapy·E HeikkiläP Huovinen
Nov 30, 1989·The American Journal of Medicine·G M Eliopoulos, C T Eliopoulos
Oct 1, 1989·Clinical Microbiology Reviews·J S Wolfson, D C Hooper
Oct 1, 1987·Antimicrobial Agents and Chemotherapy·P Huovinen

Citations

Jul 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kevin WoodPhilippe Cluzel
Jun 12, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Myung-Jin ChoiSeung-Chun Park
Sep 1, 2010·Expert Opinion on Drug Discovery·Varvara Pokrovskaya, Timor Baasov
Aug 1, 1994·Journal of the American Academy of Dermatology·S HuovinenP Huovinen
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·J G Riess
Nov 14, 2019·ChemMedChem·Benedetta FoisDanijel Kikelj

Related Concepts

Ciprinol
Drug Augmentation
Paracolobactrum
Gram-Negative Bacteria
Gram-Positive Bacteria
Fungus Drug Sensitivity Tests
Trimpex

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