Synergistic action of oncolytic herpes simplex virus and radiotherapy in pancreatic cancer cell lines

The British Journal of Surgery
M-H DaiYuman Fong

Abstract

Despite much research in chemotherapy and radiotherapy, pancreatic adenocarcinoma remains a fatal disease, highly resistant to all treatment modalities. Recent developments in the field of herpes simplex virus (HSV) engineering have allowed the generation of a number of promising virus vectors for treatment of many cancers, including pancreatic tumours. This study examined the use of one such virus, NV1023, in combination with radiation therapy in pancreatic cancer cell lines. HSV therapy in combination with radiotherapy was investigated in pancreatic cancer cell lines Hs766T, Panc-1 and MIA PaCa-2. Multiple therapy effect analysis was performed by computerized simulation. Mechanisms underlying synergy, such as virus replication and apoptosis, were investigated. The combination of NV1023 and radiation yielded a synergistic oncolytic effect in all tested pancreatic cancer cell lines, with the greatest effect achieved in MIA PaCa-2. This effect was not mediated by an increase in rapid viral replication, but by a substantial increase in apoptosis. The synergistic oncolytic actions of HSV and radiotherapy observed in pancreatic cancer cell lines encourage further testing of this multimodality treatment.

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Citations

Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Alan MelcherJohn C Bell
Apr 16, 2013·BioMed Research International·Nicolas BoisgeraultMarc Grégoire
Oct 10, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Qi LingHolger Kalthoff
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Oct 6, 2020·Frontiers in Oncology·Guo-Dong CaoMao-Ming Xiong
Mar 15, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Annette SorensenMarie Boyd

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