Synergistic activity of antibiotics combined with ivermectin to kill body lice

International Journal of Antimicrobial Agents
Abdoul Karim SangaréDidier Raoult

Abstract

Ivermectin and doxycycline have been found to be independently effective in killing body lice. In this study, 450 body lice were artificially fed on a Parafilm™ membrane with human blood associated with antibiotics (doxycycline, erythromycin, rifampicin and azithromycin) alone and in combination with ivermectin. Fluorescence in situ hybridisation and spectral deconvolution were performed to evaluate bacterial transcriptional activity following antibiotic intake by the lice. In the first series, a lethal effect of antibiotics on lice was observed compared with the control group at 18 days (log-rank test, P≤10(-3)), with a significant difference between groups in the production of nits (P=0.019, Kruskal-Wallis test). A high lethal effect of ivermectin alone (50ng/mL) was observed compared with the control group (log-rank test, P≤10(-3)). Fluorescence of bacteriocytes in lice treated with 20μg/mL doxycycline was lower than in untreated lice (P<0.0001, Kruskal-Wallis test). In the second series with antibiotic-ivermectin combinations, a synergistic lethal effect on treated lice (log-rank test, P<10(-6)) was observed compared with the control group at 18 days, associated with a significant decrease in the production of nits (P≤0.001...Continue Reading

References

Dec 1, 1991·Antimicrobial Agents and Chemotherapy·D Raoult, M Drancourt
Jan 1, 1991·Annual Review of Entomology·J A Lasota, R A Dybas
Jan 1, 1990·Journal of Medical Entomology·K Y MumcuogluR Galun
Jun 13, 1998·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S E Huffam, B J Currie
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Raoult, V Roux
Apr 13, 2000·Annual Review of Entomology·J Hemingway, H Ranson
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Ohl, D H Spach
Jan 4, 1952·Science·H S HURLBUTC NIBLEY
Apr 1, 1952·Japanese Journal of Medical Science & Biology·M KITAOKA
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bart J CurrieShelley F Walton
Jan 12, 2005·Medicine·Philippe BrouquiDidier Raoult
Jan 3, 2006·The Journal of Infectious Diseases·Cedric FoucaultPhilippe Brouqui
Jan 18, 2006·International Journal of Dermatology·Assen L DourmishevRobert A Schwartz
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·J DupuyM Alvinerie
Jan 18, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Alejandra PerottiHenk R Braig
Jun 6, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S J CutlerJ-F Trape
Oct 9, 2009·The New England Journal of Medicine·Yaya I CoulibalyAmy D Klion
Dec 3, 2009·Veterinary Parasitology·L C Perez-CogolloR J Miller
Jan 13, 2010·International Journal of Dermatology·Arumugam MunirathinamBrij Kishore Tyagi
May 21, 2010·Parasites & Vectors·Kate E MounseyJames S McCarthy
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ewen F KirknessBarry R Pittendrigh
Nov 1, 2011·International Journal for Parasitology·Paula C PohlAoi Masuda
Jun 12, 2013·Emerging Infectious Diseases·Renaud PiarrouxMichel Drancourt
Aug 16, 2014·International Journal of Antimicrobial Agents·Hui GuoLixin Zhang
Apr 4, 2015·International Journal of Antimicrobial Agents·Abdoul Karim SangaréDidier Raoult

❮ Previous
Next ❯

Citations

May 24, 2016·International Journal of Antimicrobial Agents·Georges DiattaDidier Raoult
Aug 17, 2016·BioMed Research International·Abdoul Karim SangaréDidier Raoult
Aug 7, 2018·PLoS Genetics·Nadia AmanzougagheneOleg Mediannikov
Feb 11, 2020·Parasite : Journal De La Société Française De Parasitologie·Jose E Pietri, Ritesh Ray
Mar 4, 2020·Antimicrobial Agents and Chemotherapy·Jose E Pietri, Dangsheng Liang
Mar 30, 2018·Frontiers in Cellular and Infection Microbiology·Christian StutzerChristine Maritz-Olivier
Feb 11, 2020·Frontiers in Cellular and Infection Microbiology·Nadia AmanzougagheneOleg Mediannikov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

International Journal of Antimicrobial Agents
Stacy Sommerfeld Ross, Jennifer Fiegel
Rinsho ganka. Japanese journal of clinical ophthalmology
K ISHIDA
Il Corriere dei farmacisti
G CAGNOLATI
© 2022 Meta ULC. All rights reserved