Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol.

Cancer Investigation
Hong ZhuQiao-Jun He

Abstract

The present study demonstrates that the combination of TRAIL/APO-2L and celastrol exerts strong synergistic antiproliferative effect against human cancer cells including ovary cancer OVCAR-8, colon cancer SW620, and lung cancer 95-D, with the combination indices below 0.8. Moreover, the in vivo antitumor efficacy of TRAIL/APO-2L was dramatically increased by celastrol. These enhanced anticancer activities were accompanied by the prompt onset of caspase-mediated apoptosis. Taken together, our data firstly demonstrate the synergistic anticancer capabilities achieved by combining TRAIL/APO-2L and celastrol, and moreover, open new opportunities to enhance the effectiveness of future treatment regimens using TRAIL/APO-2L.

References

Apr 4, 1997·Science·G PanV M Dixit
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Nov 1, 2001·Cell Death and Differentiation·W S El-Deiry
Oct 2, 2003·Bioscience, Biotechnology, and Biochemistry·Masahiro NagaseNobuo Sakato
Nov 25, 2003·Oncogene·Shulin Wang, Wafik S El-Deiry
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liang ZhaoJessie L-S Au
Aug 20, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ferry SandraSeiji Nakamura
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·Fan YangJian Ding
May 2, 2006·Molecular Cancer Therapeutics·Peihua LuoBo Yang
Apr 14, 2007·Molecular Cancer Therapeutics·Subrata RayAlexandru Almasan
Jan 19, 2008·Molecular Cancer Therapeutics·Tao ZhangDuxin Sun

❮ Previous
Next ❯

Citations

Aug 5, 2011·Applied Microbiology and Biotechnology·Li-Wei WangChristian P Kubicek
Nov 3, 2011·PloS One·Jakob HansenPeter Bross
Sep 8, 2011·Bioscience, Biotechnology, and Biochemistry·Yuchen LinJing Chen
May 29, 2010·Cellular and Molecular Life Sciences : CMLS·Guillaume JacqueminOlivier Micheau
Jul 3, 2013·Current Colorectal Cancer Reports·Bharat AggarwalSushovan Guha
Nov 2, 2014·International Journal of Cancer. Journal International Du Cancer·Marco Lo IaconoGiorgio Vittorio Scagliotti
Mar 27, 2015·Head & Neck·Evren ErkulHakan Cincik
Jan 24, 2012·Journal of Ethnopharmacology·Shengpeng WangYitao Wang
Apr 22, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Martina ChripkovaJan Mojzis
Aug 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Wen-Shan XuYi-Tao Wang
May 20, 2017·International Journal of Cancer. Journal International Du Cancer·Miao XianQiaojun He
Mar 30, 2016·Molecular BioSystems·Renping WangYunpeng Qi
Nov 5, 2016·Phytotherapy Research : PTR·Stephen Safe, Ravi Kasiappan
Jul 13, 2018·Chinese Medicine·Mu-Yang HuangJin-Jian Lu
Jul 10, 2019·Cancer Chemotherapy and Pharmacology·Zhe ChaHuarong Yu
Mar 30, 2017·Frontiers in Pharmacology·Saúl Redondo-BlancoFelipe Lombó
Oct 6, 2020·Frontiers in Medicine·Rita CascãoJoão Eurico Fonseca
Dec 29, 2020·Frontiers in Pharmacology·Jinfeng ShiChaomei Fu
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Priti TagdeMohamed M Abdel-Daim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.