Synergistic anti-malarial action of cryptolepine and artemisinins.

Malaria Journal
Arnold D ForkuoMichael F Ofori

Abstract

Cryptolepine (CPE) is the major indoloquinoline isolated from the popular West African anti-malarial plant, Cryptolepis sanguinolenta. CPE possesses various pharmacological activities with potent anti-malarial activity against both chloroquine (CQ)-resistant and -sensitive strains. The search for safe and novel anti-malarial agents and combinations to delay resistance development to Plasmodium falciparum directed this work aimed at evaluating the anti-malarial interaction and safety of CPE in combination with some artemisinin derivatives. The in vitro SYBR Green I, fluorescent-based, drug sensitivity assay using a fixed ratio method was carried out on the CQ-sensitive plasmodial strain 3D7 to develop isobolograms from three CPE-based combinations with some artemisinin derivatives. CPE and artesunate (ART) combinations were also evaluated using the Rane's test in ICR mice infected with Plasmodium berghei NK-65 strains in a fixed ratio combination (1:1) and fractions of their ED50s in order to determine the experimental ED50 (Zexp) of the co-administered compounds. Isobolograms were constructed to compare the Zexp to the Zadd. CPE exhibited promising synergistic interactions in vitro with ART, artemether and dihydroartemisinin. I...Continue Reading

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Citations

Jul 7, 2018·Beilstein Journal of Organic Chemistry·Sayantan BhaduriDev P Arya
Nov 11, 2017·Journal of Tropical Medicine·Siti Junaidah AhmadNoraziah Mohamad Zin
Mar 18, 2016·Malaria Journal·Arnold D ForkuoMichael F Ofori
Jun 22, 2021·Antimicrobial Agents and Chemotherapy·Joy E ChiuChoukri Ben Mamoun

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Methods Mentioned

BETA
column chromatography
light microscopy

Software Mentioned

GraphPad Prism
GraphPad

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