Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model

Nutrition
Carolina Paola GarciaM E Pasqualini

Abstract

The aim of this study was to determine the effects of some polyunsaturated fatty acids plus phytomelatonin from walnuts in the development of mammary gland adenocarcinoma. BALB/c mice were fed a semisynthetic diet supplemented with either 6% walnut oil and 8% walnut flour containing phytomelatonin (walnut diet: WD); or 6% corn oil plus commercial melatonin (melatonin diet: MD), or the control group (CD), which received only 6% of corn oil. Membrane fatty acids of tumor cells (TCs) were analyzed by gas liquid chromatography, cyclooxygenase (COX) and lipoxygenase (LOX) derivatives, and plasma melatonin by high-performance liquid chromatography; apoptosis and tumor-infiltrating lymphocytes by flow cytometry. TCs from the MD and WD mice showed significant decreases in linoleic acid compared with the CD group (P < 0.05). Significantly lower levels of LOX-[13(S)-HODE] were found in TCs from the MD and WD group than in CD (P < 0.0001). COX-[12(S)-HHT] was lower and 12 LOX-[12(S)-HETE] was higher in TCs from the MD group than form the WD and CD arms (P < 0.05). Plasma melatonin, apoptosis, tumor infiltration, and survival time were significantly lower in CD mice than in MD and WD mice (P < 0.05). This study shows that melatonin, along ...Continue Reading

References

Feb 3, 1998·Biochemical and Biophysical Research Communications·H MaruokaH Wakasugi
Dec 22, 1999·Biochimica Et Biophysica Acta·R O Calderón, A R Eynard
Oct 12, 2005·Endocrine·Margarita L Dubocovich, Magdalena Markowska
Apr 21, 2006·International Journal of Experimental Pathology·Sandra C MillerGeorges J M Maestroni
Dec 16, 2006·Current Pharmaceutical Biotechnology·Undurti N Das
Jul 16, 2008·Pharmaceutical Research·Preetha AnandBharat B Aggarwal
Dec 3, 2008·Neuroimmunomodulation·Daniel P CardinaliSeithikurippu R Pandi-Perumal
Dec 23, 2008·Cellular and Molecular Life Sciences : CMLS·P J LardoneJ M Guerrero
Feb 6, 2009·Expert Reviews in Molecular Medicine·Stephen G GrantPaula A Witt-Enderby
Mar 26, 2009·Journal of Pineal Research·Masateru Okazaki, Hiroshi Ezura
Mar 31, 2009·Journal of the American Dietetic Association·Natalie D RiedigerMohammed H Moghadasian
May 23, 2009·Toxicology and Applied Pharmacology·F RadognaL Ghibelli
Dec 18, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·A Comba, María Eugenia Pasqualini
Jun 30, 2010·Journal of the Science of Food and Agriculture·Marcela L MartínezDamián M Maestri
Nov 12, 2010·Breast Cancer Research : BCR·Mira MacLennan, David W L Ma
Jul 21, 2011·Journal of Mammary Gland Biology and Neoplasia·Steven M HillTamika Duplesis
Nov 4, 2011·Cancer Metastasis Reviews·Andrea CombaMarìa Eugenia Pasqualini
Jan 27, 2012·Journal of Ovarian Research·Hiroshi TamuraNorihiro Sugino
Sep 11, 2012·Prostaglandins & Other Lipid Mediators·Xiangsheng Zuo, Imad Shureiqi
Oct 6, 2012·Critical Reviews in Food Science and Nutrition·Laura Vera-RamirezJose L Quiles

❮ Previous
Next ❯

Citations

Oct 16, 2015·Expert Opinion on Therapeutic Targets·Jean A Boutin
Sep 11, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Emilio RosAleix Sala-Vila
Jun 15, 2019·Chronobiology International·David J Kennaway
Nov 30, 2018·Current Developments in Nutrition·Alyssa M TindallPenny M Kris-Etherton
Apr 1, 2020·International Journal of Molecular Sciences·Cinzia GiordanoDaniela Bonofiglio
Nov 18, 2018·Toxins·Elena CatanzaroCarmela Fimognari
Dec 12, 2020·Journal of Developmental Origins of Health and Disease·María Belén RabaglinoDante Beltramo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis