Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122

Bioscience Reports
Lei LiLimin Mao

Abstract

We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects.

References

Sep 1, 1969·Canadian Journal of Microbiology·A H AminK M Abbasi
May 17, 2001·Bioconjugate Chemistry· Han SoS W Kim
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tae-You KimYung-Jue Bang
Jul 30, 2005·Nature Reviews. Drug Discovery·Daniel W PackPatrick S Stayton
Nov 8, 2005·Cell·Richard I GregoryRamin Shiekhattar
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Jan 30, 2007·Oral Oncology·P K TsantoulisV G Gorgoulis
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Irina V LebedevaPaul B Fisher
Oct 24, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sangmin KimJin Ho Chung
Sep 23, 2008·Oral Oncology·Saman Warnakulasuriya
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 25, 2009·Advanced Drug Delivery Reviews·Francesca Greco, María J Vicent
Aug 10, 2010·European Journal of Pharmacology·Jeevitha B PatilG K Jayaprakasha
Jul 26, 2011·Periodontology 2000·Saman Warnakulasuriya
Feb 11, 2012·Current Medicinal Chemistry·M JafariP Chen
Jul 24, 2012·The Journal of Clinical Investigation·Shu-Hao HsuKalpana Ghoshal
Sep 22, 2012·Circulation·Fina LovrenSubodh Verma
Sep 11, 2013·Current Drug Metabolism·Brian E GrottkauYunfeng Lin
Aug 19, 2014·Oral Oncology·Narges Mirjalili, Khatere Kheirollahi
Sep 15, 2014·Antiviral Research·Meike H van der ReeHendrik W Reesink
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 17, 2014·Molecular Biology Reports·Sercan ErgünSerdar Oztuzcu
Nov 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei LuYingbin Liu

❮ Previous
Next ❯

Citations

Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Solomon Habtemariam
Jun 11, 2020·Current Pharmaceutical Design·Phui Qi NgDinesh Kumar Chellappan

❮ Previous
Next ❯

Methods Mentioned

BETA
Dynamic Light Scattering
PCR
electrophoresis
flow cytometry

Software Mentioned

ImagePro Plus

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.