Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation.

Angewandte Chemie
Shuai JiangKatharina Landfester

Abstract

The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O2 .- produced by the PDT is converted to H2 O2 by superoxide dismutase, followed by the transformation of H2 O2 to the highly toxic . OH via Fenton reactions by Fe2+ originating from the dissolution of co-loaded Fe3 O4 nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O2 .- in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O2 .- source for production of . OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.

References

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Citations

May 6, 2021·ChemMedChem·Li XuGuosheng Song
Sep 17, 2021·Chemical Communications : Chem Comm·Yingshu GuoShusheng Zhang

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Methods Mentioned

BETA
transmission electron microscopy
flow cytometry
fluorescence imaging

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