Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

International Journal of Cancer. Journal International Du Cancer
Takako Eguchi NakajimaYasuhiro Matsumura

Abstract

The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts. This study was conducted to investigate the advantages of NK012 over irinotecan hydrochloride (CPT-11) administered in combination with 5-fluorouracil (5FU). The cytotoxic effects of NK012 or SN-38 (an active metabolite of CPT-11) administered in combination with 5FU was evaluated in vitro in the human colorectal cancer cell line HT-29 by the combination index method. The effects of the same drug combinations was also evaluated in vivo using mice bearing HT-29 and HCT-116 cells. All the drugs were administered i.v. 3 times a week; NK012 (10 mg/kg) or CPT11 (50 mg/kg) was given 24 hr before 5FU (50 mg/kg). Cell cycle analysis in the HT-29 tumors administered NK012 or CPT-11 in vivo was performed by flow cytometry. NK012 exerted more synergistic activity with 5FU compared to SN-38. The therapeutic effect of NK012/5FU was significantly superior to that of CPT-11/5FU against HT-29 tumors (p = 0.0004), whereas no significant difference in the antitumor effect against HCT-116 tumors was observed between the 2-drug combinations (p = 0.2230). ...Continue Reading

References

Sep 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R AtsumiH Hakusui
Jul 1, 1994·Scientific American·R K Jain
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M L RothenbergG I Rodriguez
Mar 20, 2001·Current Oncology Reports·F M Muggia
Apr 26, 2003·Science·Radoslav SavicDusica Maysinger
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe TournigandAimery de Gramont
Jan 17, 2004·International Journal of Pharmaceutics·J Allen ZhangImran Ahmad
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rami G AzrakYoucef M Rustum
Jun 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe ColucciUNKNOWN Gruppo Oncologico Dell'Italia Meridionale
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William J GradisharJoyce O'Shaughnessy

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Citations

Aug 21, 2010·Pharmaceutical Research·Chris OerlemansWim E Hennink
Jan 30, 2010·Molecular Pharmaceutics·Vincent J Venditto, Eric E Simanek
Nov 15, 2012·Future Oncology·Pengxiao Cao, Younsoo Bae
Apr 24, 2014·Japanese Journal of Clinical Oncology·Yasuhiro Matsumura
Jul 25, 2015·Expert Opinion on Drug Delivery·Srinath Palakurthi
Jul 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Horacio Cabral, Kazunori Kataoka
Jan 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jian GongYitao Wang
Feb 10, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Emilie RogerJean-Pierre Benoit
Dec 18, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yohei SaitoYasuhiro Matsumura
Oct 9, 2008·Advanced Drug Delivery Reviews·James D ByrneLisa Brannon-Peppas
Apr 15, 2008·Advanced Drug Delivery Reviews·Yasuhiro Matsumura
Feb 4, 2009·International Journal of Cancer. Journal International Du Cancer·Jun-ichiro KurodaYasuhiro Matsumura
Mar 4, 2010·International Journal of Cancer. Journal International Du Cancer·Tatsuya NaganoYasuhiro Matsumura
Apr 12, 2016·Cancer Chemotherapy and Pharmacology·Howard A BurrisSuzanne F Jones
May 23, 2009·Cancer Science·Yasuhiro Matsumura, Kazunori Kataoka
Oct 1, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Usman ArshadAndrew Owen
Jul 27, 2011·Molecular Cancer Therapeutics·Matthias MaakKlaus-Peter Janssen
Oct 15, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tetsuya HamaguchiYasuhiro Matsumura
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun-ichiro KurodaYasuhiro Matsumura
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tatsuya NaganoYasuhiro Matsumura
Jun 20, 2015·Chemical Reviews·Yuanzeng MinAndrew Z Wang

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