Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands

Biochemical and Biophysical Research Communications
Hiroshi TakenakaKo Okumura

Abstract

Simultaneous activation of murine mast cells by monomeric IgE and toll-like receptor (TLR) ligands was examined. Inflammatory cytokine production elicited by the binding of IgE in the absence of antigen, was further enhanced by the addition of lipopolysaccharide (LPS) or peptidoglycan (PGN). Enhancement by LPS or PGN on cytokine production was mediated by TLR4 and TLR2, respectively, since TLR4- and TLR2-deficient mast cells did not show synergistic activation by monomeric IgE and LPS/PGN. Synergistic activation of mast cells was obtained via phosphorylation of several mitogen-activated protein kinases (MAPK). Furthermore, MAPK inhibitors, significantly attenuated the augmentation of inflammatory cytokine production by monomeric IgE and LPS or PGN. Altogether, these results suggest that simultaneous TLR activation of mast cells with IgE molecules, particularly highly cytokinergic (HC) IgE, might contribute to the exacerbation of allergic diseases associated with infection even in the absence of a specific antigen.

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Citations

Jul 14, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jaciel Medina-TamayoClaudia González-Espinosa
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Apr 29, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·Z SongF Hao
Mar 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens RuschmannGerald Krystal

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