Synergistic Benefit of Statin and Metformin in Gastrointestinal Malignancies

Journal of Pharmacy Practice
George K NimakoAlice C Ceacareanu

Abstract

To evaluate whether statin use influences gastrointestinal cancer prognosis in patients with diabetes mellitus (DM). We reviewed all DM patients diagnosed at Roswell Park Cancer Institute with emergent gastrointestinal malignancy (January 2003 to December 2010) (N = 222). Baseline demographic, clinical history, and cancer outcomes were documented. Overall survival (OS) and disease-free survival (DFS) comparisons across various treatment groups were assessed by Kaplan-Meier and Cox proportional hazards. Use of statin, alone or in combination, was associated with improved OS and DFS (hazard ratio [HR] = 0.65, P = .06; HR = 0.60, P < .02). We report similar OS and DFS advantage among users of mono- or combined metformin therapy (HR = 0.55, P < .01; HR = 0.63, P < .02). Concomitant use of metformin and statin provided a synergistic OS and DFS benefit (HR = 0.42, P < .01; HR = 0.44, P < .01). Despite significant tobacco and alcohol use history, patients with upper gastrointestinal cancers derived enhanced cancer outcomes from this combination (HR = 0.34, P < .01; HR = 0.43, P < .02), while receiving a statin without metformin or metformin without a statin did not provide significant cancer-related benefits. Use of statin and metform...Continue Reading

References

Apr 26, 2005·BMJ : British Medical Journal·Josie M M EvansAndrew D Morris
Dec 21, 2006·British Journal of Cancer·F KamangarS M Dawsey
May 1, 2010·International Journal of Diabetes in Developing Countries·Bikha Ram DevrajaniTarachand Devrajani
Jul 8, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N D FreedmanK E L McColl
Nov 16, 2010·Helicobacter·William NseirNimer Assy
Feb 23, 2012·Journal of Molecular Endocrinology·Ryan J O DowlingPamela J Goodwin
Mar 20, 2012·The Journal of Infectious Diseases·Yu Chen, Martin J Blaser
Jul 11, 2012·European Journal of Endocrinology·Chin-Hsiao Tseng
Feb 23, 2013·World Journal of Gastroenterology : WJG·Jae Moon YoonSang Min Park
Jul 4, 2013·Cancer Causes & Control : CCC·Claudia BeckerMichael Bodmer
Nov 23, 2013·Cancer Causes & Control : CCC·Yanqiong LiuXue Qin
Mar 4, 2014·World Journal of Gastroenterology : WJG·Chin-Hsiao Tseng, Farn-Hsuan Tseng
Nov 13, 2014·Diabetes Technology & Therapeutics·Yuxin HuangWen Tan
Nov 25, 2014·Journal of the National Cancer Institute. Monographs·Nadia HowladerLisa M Schwartz
Jan 13, 2015·Journal of Cancer Research and Therapeutics·Zhiyuan MaHaitao Li
Jan 28, 2015·Nature Reviews. Gastroenterology & Hepatology·Claire Greenhill
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 26, 2015·Journal of Pharmacy Practice·Alice C Ceacareanu
Feb 26, 2015·Journal of Pharmacy Practice·Zachary A P Wintrob
Apr 4, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Aaron P Thrift
Jun 21, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L Van De VoordeP Lambin
Aug 16, 2015·Journal of Diabetes and Its Complications·Francesca Valent
Sep 4, 2015·International Journal of Cancer. Journal International Du Cancer·Úna C Mc MenaminChris R Cardwell
Sep 10, 2015·Annals of Surgical Oncology·L E A M M SpieringsH W M van Laarhoven
Sep 18, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amy R MarksChyke A Doubeni

❮ Previous
Next ❯

Citations

Jan 5, 2017·Pediatric Diabetes·Inas Thomas, Brigid Gregg
Dec 5, 2016·Cytokine·Zachary A P WintrobAlice C Ceacareanu
Sep 29, 2018·The Journal of Clinical Endocrinology and Metabolism·Aura D Herrera-MartínezRaúl M Luque
May 6, 2020·World Journal of Gastrointestinal Oncology·Jian-Nan LiKai Zhang
Sep 11, 2020·American Journal of Clinical Oncology·Ali Fatehi Hassanabad

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.