Synergistic Benefits of Combined Aerobic and Cognitive Training on Fluid Intelligence and the Role of IGF-1 in Chronic Stroke

Neurorehabilitation and Neural Repair
Michelle PloughmanMarilyn Mackay-Lyons

Abstract

Paired exercise and cognitive training have the potential to enhance cognition by "priming" the brain and upregulating neurotrophins. Two-site randomized controlled trial. Fifty-two patients >6 months poststroke with concerns about cognitive impairment trained 50 to 70 minutes, 3× week for 10 weeks with 12-week follow-up. Participants were randomized to 1 of 2 physical interventions: Aerobic (>60% VO2peak using <10% body weight-supported treadmill) or Activity (range of movement and functional tasks). Exercise was paired with 1 of 2 cognitive interventions (computerized dual working memory training [COG] or control computer games [Games]). The primary outcome for the 4 groups (Aerobic + COG, Aerobic + Games, Activity + COG, and Activity + Games) was fluid intelligence measured using Raven's Progressive Matrices Test administered at baseline, posttraining, and 3-month follow-up. Serum neurotrophins collected at one site (N = 30) included brain-derived neurotrophic factor (BDNF) at rest (BDNFresting) and after a graded exercise test (BDNFresponse) and insulin-like growth factor-1 at the same timepoints (IGF-1rest, IGF-1response). At follow-up, fluid intelligence scores significantly improved compared to baseline in the Aerobic + ...Continue Reading

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Citations

Feb 25, 2020·Neurorehabilitation and Neural Repair·Emily RosenichSusan L Hillier
Mar 14, 2020·Journal of Neurologic Physical Therapy : JNPT·Arthur R ChavesMichelle Ploughman
Jun 26, 2020·Frontiers in Neurology·Arthur R ChavesMichelle Ploughman
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Apr 4, 2021·International Journal of Molecular Sciences·Nicolas HuguesJérôme Laurin
Dec 17, 2021·Journal of the American Heart Association·Susan MarzoliniWalter Swardfager

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