Synergistic but independent: The role of corticospinal and alternate motor fibers for residual motor output after stroke

NeuroImage. Clinical
Robert SchulzFriedhelm C Hummel

Abstract

Brain imaging has shown that not only the cortico-spinal tract (CST), but also alternate corticofugal motor fibers (aMF), such as the cortico-rubro-spinal and cortico-reticulo-spinal tract, influence residual motor output after stroke. So far, studies mainly have investigated each tract separately. A combined analysis of CST and aMF with assessment of their interactive role, i.e., that structural integrity of one tract influences the functional role of the structural integrity of the other, is pending. 39 late subacute stroke patients (aged 59.4 ± 12.0 years, 100 ± 11 days after stroke) were included. Probabilistic tractography was used to reconstruct CST and aMF. Fractional anisotropy (FA) was calculated as a measure of microstructural integrity. Multiple-linear-regression analysis was used to associate tract-related FA with residual motor output and to determine interactions between CST and aMF. Both CST (coefficient = 3.93, p < 0.0001) and aMF (coefficient = - 4.43, p = 0.003) of the affected hemisphere significantly contributed to residual motor output. An interaction of their impacts with a consecutive influence on motor output was not detected (p = 0.882). Thus, these data suggest that aMF and CST explain residual motor o...Continue Reading

Citations

Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Estelle Raffin, Friedhelm C Hummel
Jul 19, 2018·Neurorehabilitation and Neural Repair·Chia-Lin KohWen-Yih Isaac Tseng
Oct 28, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carla CirilloIsabelle Loubinoux
Jun 23, 2020·Stroke; a Journal of Cerebral Circulation·Jingchun LiuChunshui Yu
May 11, 2021·Journal of Neuroscience Methods·Allison F Lewis, Jill C Stewart
Jul 9, 2021·Brain : a Journal of Neurology·Philipp J KochFriedhelm C Hummel
Aug 6, 2021·Annals of Clinical and Translational Neurology·Conrad C PrillwitzTheodor Rüber
Aug 21, 2021·Stroke; a Journal of Cerebral Circulation·Robert SchulzChristian Gerloff

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

probtrackx
FSL
R

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