Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles.

Molecular Pharmaceutics
Youmei BaoJianjun Chen

Abstract

Breast cancer is the most common type of cancer in women. About 12% of all women in the United States will be diagnosed with breast cancer over their lifetimes. At the same time, incidences of brain metastases (BMs) are increasing and represent an emerging health threat. However, there is no effective chemotherapy for breast cancer brain metastases (BCBMs), which is largely due to lack of efficient delivery of antitumor drugs or drug combinations to the brain. In this study, oleanolic acid (OA), a natural pentacyclic triterpenoid compound with excellent antitumor activity, was found to form nanoparticles (NPs) and efficiently penetrate the brain for BCBMs treatment. On the basis of these findings, we developed a synergistic combinatorial chemotherapeutic regimen by formulating paclitaxel (PTX) into OA NPs and demonstrated that the resulting PTX-OA NPs effectively inhibited primary breast cancer and BCBMs in mouse xenografts. Collectively, this study introduces a new direction to treat primary breast cancer and BCBMs through noninvasive combination chemotherapy.

References

Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T YonedaR Nishimura
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·M A Jordan
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John F Deeken, Wolfgang Löscher
Nov 9, 2007·Breast Cancer Research and Treatment·Sung Sook LeeWoo Kun Kim
Mar 30, 2010·Expert Opinion on Pharmacotherapy·Cagatay ArslanKadri Altundag
Jun 15, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A NiwińskaP Niwiński
Aug 11, 2011·Current Pharmaceutical Design·Sagar AgarwalBjörn Bauer
Nov 25, 2011·International Journal of Nanomedicine·Yuandong MaLin Mei
Jan 3, 2012·Advanced Drug Delivery Reviews·Toral PatelW Mark Saltzman
Feb 1, 2012·The Cancer Journal·Jiangbing ZhouW Mark Saltzman
Jan 18, 2014·Molecular Cancer Therapeutics·Eiman MukhtarHasan Mukhtar
Dec 5, 2014·Molecular and Cellular Biochemistry·Xiaoming ZhaoDaotang Li
Mar 6, 2015·Journal of the American Chemical Society·Kaimin CaiJianjun Cheng
Nov 26, 2015·Experimental Hematology & Oncology·José Pablo Leone, Bernardo Amadeo Leone
May 22, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cláudia SaraivaLiliana Bernardino
Oct 22, 2016·Biomaterials·Si-Yong QinXian-Zheng Zhang
Mar 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Niege A J C FurtadoChristelle M André
Mar 17, 2017·International Journal of Molecular Sciences·Lovro ŽibernaSeyed Mohammad Nabavi
Mar 18, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Min WuYuan Ping
Jul 7, 2018·Therapeutic Advances in Medical Oncology·Nuria KoteckiAhmad Awada
Jan 23, 2019·JAMA : the Journal of the American Medical Association·Adrienne G Waks, Eric P Winer

❮ Previous
Next ❯

Citations

Jul 17, 2020·Frontiers in Pharmacology·Hong FengYuan-Fu Lu
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna KapsEwa Chodurek
Apr 10, 2021·Biomaterials·Yachao ZhangShuangying Gui
Jul 26, 2021·Advanced Drug Delivery Reviews·Ying XieJiangbing Zhou
Oct 31, 2021·Drug Delivery and Translational Research·Christine P CarneyAnthony J Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

© 2021 Meta ULC. All rights reserved