PMID: 8956338Nov 1, 1996Paper

Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats

Pharmaceutical Research
H HarashimaH Kiwada

Abstract

The effect of liposome size and cholesterol (CH) content on the pharmacokinetics of liposomes was investigated in rats. The pharmacokinetics of liposomes was examined using 5(6)-carboxyfluorescein (CF) as an aqueous phase marker. The extent of complement activation (ECA) was also measured by the release of CF from liposomes in serum. Both the size and the CH content influenced the mean residence time, total body clearance, and the hepatic uptake clearance (CLh) of liposomes. The increase of the size of liposomes increased the CLh at each CH content. There was no CH dependency of CLh in small liposomes (200 nm in diameter), although the CLh increased with the increase in the CH content in large (800 nm) and medium (400 nm) liposomes. A significant interaction effect was observed between liposome size and the CH content on CLh according to the analysis of variance. The good correlation between CLh and ECA indicated the role of complements as opsonins in enhancing the hepatic uptake of liposomes. The interaction effect between the size and CH content on CLh was explained principally by the product of the size and CH content. A synergistic effect was observed between the size and the CH content on CLh. An underlying hypothesis of t...Continue Reading

Citations

Oct 1, 2005·Journal of Liposome Research·Xuedong YanJan A A M Kamps
Sep 7, 2013·Nano LIFE·Patricia M PachecoTodd Sulchek
Jul 6, 2019·Science and Technology of Advanced Materials·Marwa MohamedTatsuhiro Ishida
Feb 4, 2006·Drug Development and Industrial Pharmacy·Sumio ChonoKazuhiro Morimoto
Sep 11, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sumio Chono
Oct 21, 2011·Journal of Liposome Research·Ana Paula Landi-LibrandiYara Maria Lucisano-Valim
Aug 7, 2009·Drug Development and Industrial Pharmacy·Sumio ChonoKazuhiro Morimoto
Mar 29, 2014·Journal of Biomedical Materials Research. Part a·Hwan-Seok JeongHwan-Jeong Jeong
Apr 18, 2001·Biological & Pharmaceutical Bulletin·T M HuongH Kiwada
Jan 18, 2007·The Journal of Pharmacy and Pharmacology·Sumio ChonoKazuhiro Morimoto
Sep 10, 2020·Nanoscale·Iara Maíra de Oliveira VianaNicolas Bertrand
Oct 23, 2009·Journal of Liposome Research·Nadia S ChiaramoniSilvia del Valle Alonso
Jan 8, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuhiro Morimoto
Feb 11, 2000·Chemistry and Physics of Lipids·M ForadadaJ Estelrich
Dec 8, 2004·Biochimica Et Biophysica Acta·X YanJ A A M Kamps
May 3, 2006·Biomaterials·Arnaud VonarbourgJean-Pierre Benoit
Oct 20, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Bingchen Li, Erwin London

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