Synergistic effect of [10]-gingerol and aminoglycosides against vancomycin-resistant enterococci (VRE)

Biological & Pharmaceutical Bulletin
Chihiro NagoshiTomofusa Tsuchiya

Abstract

An extract from ginger (root of Zingiber officinale) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). The effective compound was isolated and identified as [10]-gingerol. In the presence of [10]-gingerol at 1/10 concentration of its own MIC, the MIC of arbekacin was lowered by 1/32 to 1/16. [10]-Gingerol also reduced the MICs of other aminoglycosides, and of bacitracin and polymixin B, but not of other antimicrobial agents tested. Because [10]-gingerol reduced the MICs of several aminoglycosides both in strains possessing or lacking aminoglycoside-modification enzymes, it seems that the effect of [10]-gingerol is not related to these enzymes, which mainly confer bacterial resistance against aminoglycosides. It seemed that a detergent-like effect of [10]-gingerol potentiated the antimicrobial activity of the aminoglycosides. In fact, some detergents such as sodium dodecyl sulfate (SDS) and Triton X-100 reduced the MICs of aminoglycosides, bacitracin and polymixin B in VRE. Since the intrinsic resistance to aminoglycosides in enterococci is due to low level of entry of the drugs into the cells, increase in the membrane permeability caused by [10]-gingerol will enha...Continue Reading

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Citations

Apr 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry· EerdunbayaerTsutomu Hatano
Feb 28, 2007·Journal of Ethnobiology and Ethnomedicine·Cheryl LansWilli Boepple
Aug 1, 2015·Phytochemistry·Ruchi Badoni SemwalAlvaro M Viljoen
Apr 14, 2009·Bioorganic & Medicinal Chemistry Letters·Shichao MaWei Wang
Apr 15, 2016·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Anastasia KuttSunita Vohra
Feb 3, 2007·Biological & Pharmaceutical Bulletin·Kumiko HoriuchiTomofusa Tsuchiya
Feb 2, 2018·Applied Microbiology and Biotechnology·Bora ShinWoojun Park
Jun 1, 2010·Midwives·Denise Tiran
Aug 22, 2021·BioFactors·Roghayeh YahyazadehVahid Reza Askari
Apr 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Yi CaiTakashi Ikejima

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