Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurological function after experimental spinal cord injury

Journal of Neurosurgery
R BaffourP Friedmann

Abstract

The authors evaluated the effects of exogenous basic fibroblast growth factor (bFGF) in combination with intravenous methylprednisolone on neurological function and cord angiogenesis in a model of spinal cord injury. Cord injury was produced by extradural clip compression through a T-1 laminectomy. Rats were randomized to one of six groups. Group A was given sham laminectomy without cord injury or treatment. The remaining animals were divided into five groups: untreated injury (Group B); injury treated with methylprednisolone (Group C); combined methylprednisolone and 1 microgram bFGF administered locally at the site of injury (Group D); methylprednisolone and 3 micrograms bFGF (Group E); or methylprednisolone and 3 micrograms heated bFGF (Group F). Groups C through F received treatment 1 hour after cord injury. At 1, 2, 3, and 4 weeks after surgery, neurological function of hindlimbs was assessed by blinded observers using an established multiple test method (toe spread, reflexes to extension, pain, and pressure as well as inclined plane and swim test) with tests graded and results expressed as a combined behavioral score. Animals were killed to study spinal cord angiogenesis in cord samples (2-mm sections proximal and distal ...Continue Reading

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Citations

Apr 5, 2002·Journal of Neuroscience Research·Alexander G RabchevskyStephen W Scheff
Jul 3, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Suleyman R CayliSaim Yologlu
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Gregory D Carlson, Carey Gorden
Sep 7, 2002·Human Gene Therapy·Virginie FataccioliEmmanuel Teiger
May 22, 2009·AJR. American Journal of Roentgenology·Ayumi SekoYasuhiko Tabata
May 31, 2007·Neurological Research·Ozkan AtesSaim Yologlu
Sep 6, 2005·Journal of the Chinese Medical Association : JCMA·Pei-Hsin LinTien-Yow Chuang
Apr 9, 2013·Neuroscience Research·Sarina KundiZubair Ahmed
Apr 10, 2004·Neurological Research·Jason S BelkasRajiv Midha
Jun 26, 1999·The European Journal of Neuroscience·M OudegaM B Bunge
Jul 26, 1996·Science·W Young

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