Synergistic effect of enteral nutrition on remission induction in a patient with penetrating Crohn disease: A case report

Medicine
Chenxi XieJianlin Ren

Abstract

Crohn disease includes 3 phenotypes, inflammatory, stricturing, and penetrating. In cases where corticosteroids and immunosuppressive agents are not suitable treatment options, enteral nutrition (EN) can be used to reduce disease severity and enhance barrier defense with fewer potential adverse effects. A 23-year-old man with abdominal pain and diarrhea presented at our hospital in 2014. The frequency of defecation was 3 or 4 times a day without mucus or blood in the stool. His body mass index was 15.8, and in laboratory tests the erythrocyte sedimentation rate was 42.4 mm/h, serum C reactive protein was 65.2 mg/L, the leukocyte count was 11.64 × 109/L, and hemoglobin was 111 g/L. In computed tomography (CT) enterography the ascending colon was thickened, and there was effusion and enlarged lymph nodes around the colon. Colonoscopy revealed ulcer, polypoid proliferation, and bowel stenosis in many segments. Chronic inflammation was evident in multiple biopsies. Crohn disease was diagnosed based on the above observations. Mesalazine was administered at a dose of 4 g daily for 2 years. The patient was hospitalized again due to severe abdominal pain and ongoing fever. Intestinal perforation was detected via CT. Percutaneous draina...Continue Reading

References

Mar 23, 2002·Gastroenterology·David A SchwartzWilliam J Sandborn
Apr 6, 2011·Gut·Craig MowatUNKNOWN IBD Section of the British Society of Gastroenterology
Aug 10, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Forbes AlastairPaulon Emma
Oct 30, 2012·European Journal of Gastroenterology & Hepatology·Rute Maria Cerqueira, Paula M Lago
Jan 21, 2014·Journal of Clinical Gastroenterology·Dong HuJieshou Li
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Kamal V PatelPeter M Irving
Jan 31, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Alastair ForbesStephan C Bischoff

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BETA
biopsies
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