Synergistic effect of iontophoresis and a series of fatty acids on LHRH permeability through porcine skin

Journal of Pharmaceutical Sciences
K S Bhatia, J Singh

Abstract

The effect of chemical penetration enhancers (e.g., fatty acids) in combination with iontophoresis was examined on the in vitro permeability of luteinizing hormone releasing hormone (LHRH) through porcine skin. Porcine epidermis was pretreated with either ethanol (EtOH) or 10% fatty acid/EtOH. The permeability coefficient of LHRH was significantly (p < 0.05) greater through EtOH, lauric acid/EtOH, palmitic acid/EtOH, oleic acid/EtOH, linoleic acid/EtOH, and linolenic acid/EtOH treated epidermis than the control (untreated epidermis). Iontophoresis further enhanced the permeability of LHRH (p < 0.05) through enhancer-pretreated epidermis in comparison with corresponding passive permeability. Among saturated fatty acids tested, 10% palmitic acid/iontophoresis showed the highest permeability coefficient [(59.52 +/- 2.40) x 10(-4) cm/h], which was approximately 16-fold higher than that of the control [(3.57 +/- 0.41) x 10(-4) cm/h]. Unsaturated cis-octadecenoic acids were more effective penetration enhancers when compared with octadecanoic acid. Among cis-octadecenoic acids in combination with EtOH, the greater iontophoretic permeability coefficient [(59.18 +/- 12.43) x 10(-4) cm/h] was obtained through linolenic acid treated epide...Continue Reading

References

Dec 1, 1992·Pharmaceutical Research·M Y LuG S Rao
Mar 1, 1991·Pharmaceutical Research·B OngpipattanakulM L Francoeur
Dec 1, 1990·Journal of Pharmaceutical Sciences·T Ogiso, M Shintani
Jul 1, 1990·Journal of Pharmaceutical Sciences·V SrinivasanC R Behl
May 1, 1989·Journal of Pharmaceutical Sciences·V SrinivasanC R Behl
Jul 1, 1987·The Journal of Pharmacy and Pharmacology·B W Barry, S L Bennett
Oct 1, 1987·Pharmaceutical Research·T LoftssonN Bodor
Feb 1, 1988·Journal of Pharmaceutical Sciences·R R Burnette, B Ongpipattanakul
Jan 1, 1987·Journal of Pharmaceutical Sciences·G M GoldenR O Potts
Jun 1, 1985·Journal of Pharmaceutical Sciences·E R CooperR L Smith
Mar 30, 1985·Toxicology and Applied Pharmacology·R H GuyH I Maibach
Jan 1, 1969·The Journal of Investigative Dermatology·R J ScheupleinD J MacFarlane
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·J H Collett, N A Dickinson
Jul 1, 1982·Journal of Pharmaceutical Sciences·W L Hayton, T Chen
Mar 1, 1995·Journal of Pharmaceutical Sciences·K YonetoS K Li
Sep 1, 1993·Pharmaceutical Research·A KimR H Guy
Dec 1, 1963·Archives of Dermatology·A M KLIGMAN, E CHRISTOPHERS

❮ Previous
Next ❯

Citations

Aug 7, 2012·Archives of Pharmacal Research·Chung Kang, Sang-Chul Shin
Mar 17, 2004·Advanced Drug Delivery Reviews·Yogeshvar N KaliaRichard H Guy
Oct 16, 2003·International Journal of Pharmaceutics·Gai Ling LiJoke A Bouwstra
Aug 14, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·B W Barry
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S Santoyo, P Ygartua
Jan 10, 2003·Biological & Pharmaceutical Bulletin·Shao Jun Jiang, Xiao Jun Zhou
Feb 1, 2014·Archives of Dermatological Research·Umesh K Patil, Richa Saraogi
Jun 21, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abhishek Juluri, S Narasimha Murthy
Dec 8, 2004·Pharmaceutical Development and Technology·Sumeet K Rastogi, Jagdish Singh
Mar 25, 2011·Expert Opinion on Drug Delivery·Taís GratieriYogeshvar N Kalia
Feb 26, 2009·Drug Development and Industrial Pharmacy·Jae-Haeng Song, Sang-Chul Shin
Aug 8, 2008·Drug Delivery·Min-Jung KimHan-Gon Choi
Jun 12, 2009·Drug Delivery·Cheong-Weon ChoSang-Chul Shin
Jul 3, 2004·International Journal of Dermatology·William W TingRichard D Sontheimer
Jan 5, 2000·The Journal of Investigative Dermatology·S J JiangS H Lee
May 5, 2016·Drug Development and Industrial Pharmacy·Rakesh Kumar, Vivek Ranjan Sinha
Oct 26, 2018·Pharmaceutics·Cristina PadulaPatrizia Santi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.