Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms

Letters in Applied Microbiology
Renátó KovácsLászló Majoros

Abstract

Antifungal lock therapy has received significant interest in the last few years because the frequently usage of intravascular devices is associated with an increasing number of catheter-related bloodstream infections caused by Candida species. Antifungal combinations with synergistic interaction can be a good choice for antifungal lock therapy; therefore, interactions were examined between two echinocandins (caspofungin and micafungin) and the chitin synthesis inhibitor nikkomycin Z against Candida albicans and C. parapsilosis biofilms. Susceptibility was evaluated using the XTT-based checkerboard microdilution method, while the nature of interactions was assessed by calculating fractional inhibitory concentration indices and using the Bliss independence model. Mathematic-based evaluations were supplemented with fluorescent LIVE/DEAD viability assay. The results obtained by statistical interaction analyses correlated well with the viability assay. The tested echinocandins with nikkomycin Z caused an extended cell death and the structure of the biofilm was sparse compared to the control, especially for C. albicans. The findings support the simultaneous usage of nikkomycin Z and caspofungin or micafungin in alternative therapies ...Continue Reading

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Citations

Mar 19, 2020·Current Pharmaceutical Design·Kleber Santiago SilvaMaristela Pereira
Jul 8, 2020·Journal of Fungi·Renátó Kovács, László Majoros
Nov 5, 2020·MBio·Giuseppe Buda De CesareMichael C Lorenz
Dec 3, 2020·Frontiers in Microbiology·Carmen Rodríguez-CerdeiraJosé Luís González-Cespón
Jan 26, 2020·Microorganisms·Sofia Costa-de-Oliveira, Acácio G Rodrigues
Jan 20, 2020·International Journal of Antimicrobial Agents·A L BidaudE Dannaoui
Jun 2, 2021·ACS Applied Materials & Interfaces·Sebastian SchaeferCyrille Boyer
Jul 8, 2021·Expert Opinion on Pharmacotherapy·Adam G Stewart, David L Paterson
Aug 6, 2021·Journal of Basic Microbiology·Saraswathi NagarajShoba Narayan

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