Synergistic Effect of Rapamycin and Metformin Against Age-Dependent Oxidative Stress in Rat Erythrocytes

Rejuvenation Research
Abhishek Kumar SinghSyed Ibrahim Rizvi

Abstract

Erythrocytes are particularly vulnerable toward age-dependent oxidative stress-mediated damage. Caloric restriction mimetics (CRMs) may provide a novel strategy for the maintenance of redox balance as well as effective treatment of age-associated diseases. Herein, we have investigated the beneficial effect of cotreatment with CRM-candidate drugs, rapamycin (an immunosuppressant drug and inhibitor of mammalian target of rapamycin) and metformin (an antidiabetic biguanide and activator of adenosine monophosphate kinase), against aging-induced oxidative stress in erythrocytes and plasma of aging rats. Male Wistar rats of age 4 (young) and 24 months (old) were coexposed to rapamycin (0.5 mg/kg body weight [b.w.]) and metformin (300 mg/kg b.w.), and data were compared with the response of rats receiving an independent exposure to these chemicals at similar doses. The exposure of individual candidate drugs significantly reversed the age-dependent alterations in the endpoints associated with oxidative stress such as reactive oxygen species, ferric reducing ability of plasma, malondialdehyde, reduced glutathione, plasma membrane redox system, plasma protein carbonyl, and acetyl cholinesterase in erythrocytes and plasma of aging rats. H...Continue Reading

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Citations

Oct 23, 2018·Rejuvenation Research·Josh Mitteldorf
Mar 18, 2019·Biochemistry. Biokhimii︠a︡·J Mitteldorf
Jun 19, 2020·International Journal of Molecular Sciences·Qinhong Wang, Rahima Zennadi
Aug 1, 2020·Chronobiology International·Avnish Kumar VermaSyed Ibrahim Rizvi
Nov 10, 2020·Rejuvenation Research·Shambhoo Sharan TripathiSyed Ibrahim Rizvi

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