Synergistic Effect of Rubus crataegifolius and Ulmus macrocarpa Against Helicobacter pylori Clinical Isolates and Gastritis

Frontiers in Pharmacology
Jung Uoon ParkYoung Ik Lee

Abstract

Helicobacter pylori is one of the most widespread infections involved in the pathogenesis of chronic gastritis, peptic ulcer, and gastric cancer. Hence, there is an urgent need to develop medications against H. pylori. This study aimed to evaluate synergistic effect of Rubus crataegifolius (RF) and Ulmus macrocarpa Hance (UL) against H. pylori. Antibacterial susceptibility of each extract either separately or in combination was studied against two H. pylori standard strains and 11 clinical isolates using agar dilution method. The effect of the extracts on H. pylori inoculated Balb/c mice model was also studied using single dosing (100 mg/kg each) approach. The MIC50 of RF and UL were more than 100 and 200 µg/ml, respectively, against the tested strains. However, simultaneous treatment with RF and UL at 75 and 50 µg/ml, respectively, showed decreased viable cell number, MIC70, and at 75 µg/ml each showed synergic effect with MIC90. On H. pylori inoculated Balb/c mice model, RF and UL separately (100 mg/kg each) showed moderate anti-H. pylori effect, while simultaneous treatment of RF and UL with same dose showed significant synergistic anti-gastric effects in stomach. The results showed a significant synergistic effect of plants...Continue Reading

References

Jul 2, 1999·Antimicrobial Agents and Chemotherapy·K MabeT Takahashi
Aug 29, 2007·Phytotherapy Research : PTR·Hyun Mo YangJin-Kyung Kim
Feb 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Emiko RimbaraDavid Y Graham
Mar 30, 2012·Clinical and Experimental Gastroenterology·Javier P Gisbert, Xavier Calvet
Apr 12, 2012·Gut·Peter MalfertheinerUNKNOWN European Helicobacter Study Group
Jan 9, 2013·Journal of Applied Microbiology·J C Brown, X Jiang
Oct 25, 2013·Archives of Pharmacal Research·Mohammed HosnySunny Kyung-Seon Lee
Aug 2, 2014·World Journal of Gastroenterology : WJG·Hiroaki TakeuchiTetsuro Sugiura
Apr 19, 2016·Journal of Gastroenterology and Hepatology·Jyh-Ming LiouJaw-Town Lin
Oct 28, 2017·Applied Microbiology and Biotechnology·Kamila GoderskaTeresa Alarcon

❮ Previous
Next ❯

Citations

Sep 3, 2021·Planta medica·Thaise BoeingArquimedes Gasparotto Junior

❮ Previous
Next ❯

Software Mentioned

SPSS
R

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.