Synergistic effect of status epilepticus and ischemic brain injury on mortality

Epilepsy Research
E J WaterhouseR J DeLorenzo

Abstract

Ischemic brain injury (stroke) is a major cause of status epilepticus (SE). In our database of 529 adult SE cases, acute or remote cerebrovascular accidents (CVA) were a primary cause of SE for 41% of the patients overall and for 61% of the elderly patients. SE in the setting of acute CVA has a very high mortality, approaching 35%. The degree to which mortality can be attributed to the severity of the underlying CVA etiology vs. the effect of SE has not been evaluated. To address this issue, we prospectively studied patients with SE and acute CVA and compared them to control populations with acute CVA alone or with SE and remote CVA. The groups did not significantly differ with regard to age, sex, or radiographic lesion size. Mortality was unrelated to lesion size in the CVA and SE group. Overall, acute CVA and SE patients had an almost three-fold increase in mortality compared to the CVA group and an eight-fold increase compared to the SE and the non acute (remote) CVA group. Logistic regression analysis demonstrated a statistically significant synergistic effect of SE and CVA on mortality. This is the first study to document that the high mortality of SE and acute CVA is not solely due to the severity of the underlying CVA et...Continue Reading

References

Aug 1, 1978·Neurology·J P MohrH L Bleich
Jan 1, 1992·Epilepsia·R J DeLorenzoD Ko
Nov 27, 1991·JAMA : the Journal of the American Medical Association·J P KellyB K Kleinschmidt-DeMasters
Dec 1, 1990·Seminars in Neurology·R J DeLorenzo
Jun 1, 1990·Journal of Neurology·C Y Sung, N S Chu
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottM Walker
Jul 1, 1989·Acta Neurologica Scandinavica·C Y Sung, N S Chu
Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·S R GuptaF A Rubino
Oct 1, 1987·Neurology·A KerteszT Carr
Sep 1, 1987·Annals of Neurology·R KuznieckyW Feindel
Jan 1, 1985·Epilepsia·R P Simon
Nov 1, 1985·Epilepsia·G SechiG Rosati
Oct 1, 1972·Neurology·G G CelesiaM J Murphy
Jan 1, 1971·Brain : a Journal of Neurology·J M Oxbury, C W Whitty
Mar 1, 1983·Stroke; a Journal of Cerebral Circulation·G A DonnanP F Bladin
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·S C KunitzP A Wolf
Mar 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·S D ShorvonY L Yu
Jul 27, 1984·JAMA : the Journal of the American Medical Association·R L Saunders, R E Harbaugh
Mar 1, 1983·Archives of Neurology·V T Miller
May 1, 1981·Annals of Neurology·C F TerrenceJ A Perper
Nov 1, 1980·The American Journal of Medicine·M J Aminoff, R P Simon
Jul 1, 1995·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R J DeLorenzoJ G Boggs
Jun 1, 1995·Seminars in Ultrasound, CT, and MR·J CinnamonJ H Dorey
Jan 1, 1994·Epilepsia·A R TowneR J DeLorenzo
Jan 1, 1993·Epilepsia·M E LancmanR Granillo
Mar 1, 1993·Neurology·D H Lowenstein, B K Alldredge
Jan 1, 1989·Neurochemistry International·M J NealM A Shah
Jan 1, 1992·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·C R GomezJ B Selhorst

❮ Previous
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Citations

Aug 23, 2006·Der Nervenarzt·F BösebeckC Kellinghaus
Mar 28, 2009·Der Nervenarzt·H M Hamer
Oct 16, 2012·Neurocritical Care·Matthew FergusonM Brandon Westover
Aug 29, 1998·Epilepsy Research·J G BoggsR J DeLorenzo
Aug 14, 2003·Seizure : the Journal of the British Epilepsy Association·Eliana GarzonAmérico Ceiki Sakamoto
Mar 13, 2012·British Journal of Anaesthesia·A PerksR Mohanraj
Jun 2, 2000·Critical Care Medicine·J J Caronna, J P Stübgen
Sep 9, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·K G Jordan
Dec 17, 2008·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Peter Kinirons, Colin P Doherty
May 3, 2012·The Neurologist·Pedro Beleza
Jul 5, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kimberly Statler Bennett
Aug 5, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Frank W DrislaneDonald L Schomer
Jun 5, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Amy Z CrepeauKevin E Chapman
Jul 8, 2000·Epilepsia·N B Fountain
Jan 19, 2006·Epilepsia·Frank W Drislane
Jul 20, 2007·Epilepsia·Miquel Raspall-ChaureRod C Scott
Mar 11, 2008·Epilepsia·Felix RosenowSusanne Knake
Sep 12, 2009·Epilepsia·Gerhard Bauer, Eugen Trinka
Sep 4, 2004·Epilepsy Currents·Jane G. Boggs
Oct 24, 2007·Archives of Disease in Childhood·Claire L NovorolRod C Scott
Aug 9, 2007·Gerontology·Stefan BeyenburgMarkus Reuber
Aug 4, 2004·Drugs & Aging·José M Ferro, Francisco Pinto
Nov 19, 2008·QJM : Monthly Journal of the Association of Physicians·M-H TsaiC-H Lu
Jan 29, 2013·Neurology International·Telma M R de AssisOsvaldo J M Nascimento
Jun 22, 2005·Current Treatment Options in Neurology·Trudy Pang, Lawrence J Hirsch
Jan 31, 2012·Neurologic Clinics·Brandon Foreman, Lawrence J Hirsch
Jul 22, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·José L Fernández-TorreMiguel A Hernández-Hernández
Feb 17, 2009·Emergency Medicine Clinics of North America·Dan MillikanRobert Silbergleit
Jan 10, 2009·Epilepsy & Behavior : E&B·Christoph KellinghausMichael Besselmann
Jul 30, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xi-Chun M LuFrank C Tortella
Dec 15, 2010·Acta Neurologica Scandinavica·H Stefan
Aug 18, 2006·Lancet Neurology·Miquel Raspall-ChaureRod C Scott
Jul 16, 2014·Seizure : the Journal of the British Epilepsy Association·Devender BhallaPierre-Marie Preux
May 7, 2015·Experimental Neurology·Chiping WuLiang Zhang
Jun 17, 2015·Seizure : the Journal of the British Epilepsy Association·Sita JayalakshmiMohandas Surath
Oct 19, 2006·Epilepsia·Kenneth G Jordan, Lawrence J Hirsch
Apr 12, 2016·Nature Reviews. Neurology·Raoul SutterPeter W Kaplan
Dec 8, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J J HalfordS M LaRoche
May 9, 2014·Seizure : the Journal of the British Epilepsy Association·Lara V MarcuseMadeline Fields
Dec 24, 2002·Seizure : the Journal of the British Epilepsy Association·Nazire AfsarCanan Sykut-Bingol
Dec 7, 2011·Epilepsy & Behavior : E&B·J Chris SackellaresKevin M Kelly
Sep 23, 2008·Handbook of Clinical Neurology·Christopher F Bladin, Natan Bornstein
Aug 19, 2016·Journal of Clinical Medicine·Sebastián Sánchez, Fred Rincon
Dec 1, 2007·Journal of Intensive Care Medicine·Daniel J Costello, Andrew J Cole

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