Synergistic effect of the Bacillus thuringiensis toxins CryIAa and CryIAc on the gypsy moth, Lymantria dispar.

Applied and Environmental Microbiology
M K LeeD H Dean

Abstract

The insecticidal activity of toxins CryIAa, CryIAb, and CryIAc against Lymantria dispar (gypsy moth) and Bombyx mori (silkworm) was examined by force-feeding bioassays. Toxin CryIAa exhibited higher toxicity than toxins CryIAb and CryIAc for L. dispar and B. mori. To evaluate possible synergism among these toxins, bioassays were performed with mixtures of CryIAa and CryIAb, CryIAb and CryIAc, and CryIAa and CryIAc. Expected toxicity was calculated from the activity of each individual toxin and its proportion in the mixture by using the equation described by Tabashnik (B. E. Tabashnik, Appl. Environ. Microbiol. 58:3343-3346, 1992). Observed 50% growth-inhibitory doses were calculated from mixing experiments by probit analysis. In L. dispar bioassays, synergism was observed with a mixture of CryIAa and CryIAc while a mixture of CryIAa and CryIAb exhibited an antagonistic effect. No synergistic effect on B. mori was observed with any toxin combination. Voltage clamping assays of isolated L. dispar midguts also demonstrated that the mixture of CryIAa and CryIAc induced a greater slope of inhibition of short circuit current than did other toxin combinations.

References

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Citations

Sep 6, 2003·Applied and Environmental Microbiology·Mohd Amir F AbdullahDonald H Dean
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jiang ChenMichael J Adang
Dec 24, 2011·PloS One·Harmen P HendriksmaIngolf Steffan-Dewenter
Dec 17, 2014·Toxins·Leopoldo PalmaPrimitivo Caballero
Jun 3, 2015·Plant Biotechnology Journal·Adinda De SchrijverKees van Frankenhuyzen
Jun 27, 2009·Environmental Science and Pollution Research International·Christoph Then
Mar 5, 2016·Microbiology and Molecular Biology Reviews : MMBR·Maissa ChakrounJuan Ferré
Sep 6, 2012·Evolutionary Applications·Jenny S Cory, Michelle T Franklin
Feb 2, 2019·Applied Biochemistry and Biotechnology·Camila Soares FigueiredoJanete Apparecida Desidério
May 1, 1999·Applied and Environmental Microbiology· del Rincon-Castro MCJ E Ibarra
May 1, 1999·Applied and Environmental Microbiology·P ChengA Aronson
Dec 3, 1998·Applied and Environmental Microbiology·L MassonR Frutos
Jan 23, 2018·The Plant Journal : for Cell and Molecular Biology·Xu-Jing WangZhi-Xing Wang
Mar 21, 2002·Biochimica Et Biophysica Acta·Luke MassonRoland Brousseau
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·E SchnepfD H Dean
May 1, 1997·Applied and Environmental Microbiology·O PeyronnetR Laprade
Jun 27, 2006·Journal of Invertebrate Pathology·Karlygash G AimanovaSarjeet S Gill

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