Synergistic effect of the interaction between naproxen and citral on inflammation in rats

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Mario I OrtizPaulina Aguilar-Robles

Abstract

The combination of non-steroidal anti-inflammatory drugs with herbs having analgesic effects can increase their antinociceptive activity and limit their side effects. The aim of the present study was to examine the effects on inflammation and gastric injury in rats resulting from the interaction between naproxen and citral. Naproxen, citral, or fixed-dose naproxen-citral combinations were administered orally and their anti-inflammation (carrageenan-induced paw edema) and gastric damage were assessed in rats. The pharmacological interaction type was evaluated by the isobolographic analysis. Naproxen, citral, or combinations of naproxen and citral produced anti-inflammatory effects. The sole administration of naproxen produced significant gastric damage, but this effect was not obtained with either citral or combinations. ED(30) values were estimated for the individual drugs, and isobolograms were constructed. The derived theoretical ED(30) for the anti-inflammatory effect was 504.4 mg/kg; this was significantly higher than the observed experimental value (190.6 mg/kg). These results indicate that a synergistic interaction underlies the anti-inflammatory effect. The data suggests that the naproxen-citral combination can interact ...Continue Reading

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Citations

Nov 6, 2010·Archives of Pharmacal Research·Mario I OrtizRaquel Cariño-Cortés
Jan 1, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Héctor Ponce-MonterRaquel Cariño-Cortés
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Oct 14, 2014·Expert Opinion on Drug Metabolism & Toxicology·Sophia Yui Kau FongZhong Zuo
Nov 11, 2016·Canadian Journal of Physiology and Pharmacology·Mario I Ortiz
Jun 23, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E M A MacedoF R C Almeida
Apr 9, 2019·Drug Development Research·Elizabeth A Pineda-PeñaAndrés Navarrete Castro
Nov 9, 2019·Foodborne Pathogens and Disease·Chao ShiXiaodong Xia
Oct 8, 2019·Current Cancer Drug Targets·Martyna Godzieba, Slawomir Ciesielski
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohd AdilH P Vasantha Rupasinghe
Mar 21, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hellen Braga MartinsLucas M Marques
Dec 16, 2020·Drug Development Research·Martha Ivonne Sánchez-TriguerosAracely Evangelina Chávez-Piña
Jan 29, 2020·Journal of Ethnopharmacology·Gabriela Soledad Barragán-ZarateDiego Manuel Hernández-Benavides
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Rodríguez-SilverioJesús Arrieta

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