PMID: 7026821May 1, 1981Paper

Synergistic effect of thiamphenicol and cephalothin on Bacterioides fragilis (author's transl)

The Japanese journal of antibiotics
M IsonoK Ueno

Abstract

Synergistic effect of thiamphenicol (TP) and cephalothin (CET) on Bacteroides fragilis was proved in vitro. Especially its effect was much clear on B. fragilis which is possible to produce beta-lactamase. Synergistic bactericidal effect of TP and CET was proved. Chemotherapeutic effect of TP and CET against experimental mixed infectious mouse due to E. coli (beta-lactamase -) and B. fragilis (beta-lactamase +) was proved.

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