Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor

Life Sciences
Janice C ParkerFeng Gao

Abstract

The effects on insulin secretion from INS-1 cells of varying concentrations of the sulfonylurea glyburide and the PDE3 inhibitor milrinone, separately and in combination were measured. Over a range of concentrations the effects of the two drugs in combination were more than additive. A response surface model was fit to the data and was found to describe the data well. From this model, it was apparent that a significant synergistic effect upon insulin secretion existed over a wide range of combinations of the two drugs.

References

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Citations

May 17, 2011·PloS One·Rosa Di PaolaLucia Frittitta
Jun 27, 2019·Archives of Physiology and Biochemistry·Agnieszka Kilanowska, Tomasz Szkudelski

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