Synergistic effects of acute hypoxemia and hypercapnic acidosis in conscious dogs. Renal dysfunction and activation of the renin-angiotensin system

Circulation Research
C E RoseR M Carey

Abstract

The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.18 +/- 0.02), acute hypoxemia alone (Pao2 = 32 +/- 1 mm Hg, Paco2 = 32 +/- 1mm Hg, pH = 7.34 +/- 0.01), and acute hypercapnic acidosis alone (Pao2 = 82 +/- 2 mm Hg, Paco2 = 51 +/- 1 mm Hg, pH = 7.18 +/- 0.02). Although mean arterial pressure, cardiac output, and heart rate increased during combined hypoxemia and hypercapnic acidosis, effective renal plasma flow and glomerular filtration rate decreased. In addition, filtered sodium load and urinary sodium excretion decreased during combined hypoxemia and hypercapnic acidosis. Either acute hypoxemia or hypercapnic acidosis alone resulted in increased mean arterial pressure, cardiac output, and heart rate. However, in contrast to their combined effects, renal hemodynamic function was unchanged and natriuresis was observed. Measurement of plasma renin activity and angiotensin II concentrations indicated that hypoxemia or hypercapnic acidosis alone resulted in moderate a...Continue Reading

References

Jan 1, 1977·Postgraduate Medical Journal·P Daggett
Feb 1, 1979·Kidney International·A S BernsP E Arnold
Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R M CareyC R Ayers
Oct 1, 1976·Journal of Applied Physiology·R M ZakheimM Park
Mar 1, 1976·The American Journal of Physiology·M L WeissmanR R Sonnenschein
Dec 1, 1970·The Journal of Endocrinology·R E TuffleyE S Williams
Jun 5, 1971·British Medical Journal·R J White, D F Woodings
Jan 1, 1983·Endocrinology·N R LevensR M Carey
Jan 11, 1980·European Journal of Pharmacology·G Feuerstein, N Feuerstein
Jun 1, 1953·The American Journal of Physiology·F P FERGUSONC F HENDRICKSON
Sep 1, 1956·Clinica Chimica Acta; International Journal of Clinical Chemistry·A HEYROVSKY
Mar 1, 1961·The Journal of Physiology·E ULLMANN
May 28, 1960·Lancet·E J CAMPBELL, D S SHORT
May 1, 1960·Tuberkulózis·F KOVATSI HUTAS
Jun 1, 1965·The American Journal of Physiology·J K HEALYG E SCHREINER
Jan 1, 1952·Journal of Applied Physiology·D R AXELROD, R F PITTS
Jan 1, 1942·The Journal of Clinical Investigation·R A LewisS S Dorrance
Jul 1, 1949·The Journal of Clinical Investigation·E Y BergerM Pruss

❮ Previous
Next ❯

Citations

Jun 9, 2005·Critical Care Medicine·Jan Willem KuiperFrans B Plötz
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·N V Olsen
May 12, 2012·Journal of Veterinary Internal Medicine·G L HoareauP Verwaerde
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Ives HubloueMarc Leeman
Feb 27, 2009·Intensive Care Medicine·Michael DarmonLaurent Brochard
Feb 8, 2008·American Journal of Physiology. Renal Physiology·Jeffrey B HoagBrett A Simon
Aug 9, 2017·Scientific Reports·Tameshwar GaneshHai-Ling Margaret Cheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.