Synergistic effects of corticotropin and insulin-like growth factor I on corticotropin receptors and corticotropin responsiveness in cultured bovine adrenocortical cells.

Biochemical and Biophysical Research Communications
A PenhoatJ M Saez

Abstract

Pretreatment of bovine adrenocortical cells with increasing concentrations of insulin-like growth factor I (IGF-I) for 3 days resulted in a dose dependent (ED50 congruent to 5 ng/ml) increment in Corticotropin (ACTH) receptors. Moreover, IGF-I pretreatment potentiated the effects of maximal active concentration of ACTH (10(-9) M) on its own receptors. Whereas ACTH (10(-9) M) or IGF-I (50 ng/ml) alone induced a 3- and 2.5-fold increase respectively in ACTH receptors, there was a 7.5 fold increase in the presence of the two peptides. This synergism between ACTH and IGF-I was also observed for the ACTH-induced cortisol response with an increase of 9-, 3- and 20-fold for cells pretreated with ACTH, IGF-I and the two peptides, respectively. However, the effects of both peptides on ACTH-induced cAMP production was only additive. The present results show that ACTH and IGF-I are potent stimulating factors on bovine adrenal cell differentiated functions and that the effects of both peptides are synergistic.

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A PenhoatJ M Saez
Aug 30, 1989·Biochemical and Biophysical Research Communications·I LouveauJ M Saez
Jan 1, 1988·Annual Review of Physiology·E R Simpson, M R Waterman
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Dec 1, 1985·Endocrinology·J M HammondM M Rechler

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Citations

Sep 24, 2004·The Journal of Membrane Biology·S Dupré-AucouturierA Bilbaut
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·O AvalletJ M Saez
Dec 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M T Pham-Huu-TrungM Binoux
Sep 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·I ViardJ M Saez
Oct 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·N Picard-HagenP Durand
Jan 1, 1991·Progress in Growth Factor Research·J J Feige, A Baird
Sep 1, 1993·Trends in Endocrinology and Metabolism : TEM·R D Cone, K G Mountjoy
Jun 1, 1997·Endocrine Reviews·S Mesiano, R B Jaffe
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Sylvie Dupré-AucouturierAndré Bilbaut
Oct 21, 2000·Endocrine Reviews· Challis JRGS J Lye
Apr 1, 1993·Equine Veterinary Journal. Supplement·J R ChallisK Yang
Feb 1, 1994·Molecular and Cellular Endocrinology·K G MountjoyR D Cone

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