Synergistic Effects of Electrical Stimulation and Aligned Nanofibrous Microenvironment on Growth Behavior of Mesenchymal Stem Cells

ACS Applied Materials & Interfaces
Lin JinJianhua Hao

Abstract

Incontrollable cellular growth behavior is a significant issue, which severely affects the functional tissue formation and cellular protein expression. Development of natural extracellular matrix (ECM) like biomaterials to present microenvironment cues for regulation of cell responses can effectively overcome this problem. The external simulation and topological characteristics as typical guiding cues are capable of providing diverse influences on cellular growth. Herein, we fabricated two-dimensional aligned conductive nanofibers (2D-ACNFs) by an electrospinning process and surface polymerization, and the obtained 2D-ACNFs provided the effects of both alignment and electrical stimulation (ES) on cellular response of human mesenchymal cells (hMSCs). The results of cellular responses implied that the obtained 2D-ACNFs could offer a synergistic effect of both ES and aligned nanopattern on hMSC growth behavior. The effects could not only promote hMSCs to contact each other and maintain cellular activity but also provide positive promotion to regulate cellular proliferation. Thus, we believe that the obtained 2D-ACNFs will have a broad application in the biomedical field, such as cell culture with ES, directional induction for cell...Continue Reading

References

Nov 27, 2009·Nature·Matthias P LutolfHelen M Blau
Jun 11, 2010·Nature·Martin F Pera, Patrick P L Tam
Apr 21, 2012·Journal of Biomedical Nanotechnology·Lin JinQing Jiang
Oct 8, 2014·Nature Reviews. Endocrinology·Elisabeth M Walczak, Gary D Hammer
Dec 17, 2015·ACS Applied Materials & Interfaces·Lin JinZhenling Wang
Feb 3, 2016·ACS Applied Materials & Interfaces·Lin JinZhenling Wang
Oct 7, 2016·Advanced Healthcare Materials·Jiang JiangJingwei Xie
Jan 23, 2017·Biomaterials·Shira LandauShulamit Levenberg
Jan 25, 2017·ACS Applied Materials & Interfaces·Hatef Ghasemi HamidabadiMazaher Gholipourmalekabadi
Jan 27, 2017·ACS Applied Materials & Interfaces·Sowmya Selvaraj, Nishter Nishad Fathima
Mar 6, 2017·Acta Biomaterialia·Ashley R MurphyNeil R Cameron
Apr 14, 2017·Advanced Healthcare Materials·Yun XuLiang Chen
Apr 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lin JinQing Jiang
Jan 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lin JinDongping Sun
May 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tong WuXiumei Mo
Mar 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingfa ZhangZhiqiang Su
May 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kai LiuYong Zhao
Apr 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shelby AllisonEmilio I Alarcon

❮ Previous
Next ❯

Citations

Sep 14, 2019·Materials·Dinesh K Patel, Ki-Taek Lim
Nov 9, 2018·Frontiers in Bioengineering and Biotechnology·Anna DenchaiElisa Mele
Jul 10, 2019·Advanced Materials·Haitao LiuJianhua Qin
Jul 6, 2021·Biomaterials Science·Fábio F F GarrudoFrederico Castelo Ferreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved